{"product_id":"biolegend-362005","title":"Biolegend, 362005, APC anti-human CD130 (gp130) Antibody, 25tests","description":"\u003cp\u003eCD130, also known as gp130 (glycoprotein 130), IL6ST (IL-6-receptor-associated signal transducer), or common β chain, is a member of the hematopoietic cytokine receptor family. CD130 is a common subunit associated with the receptors for several cytokines, such as IL-6, IL-11, Oncostatin M (OSM), CNTF (ciliary neurotrophic factor), CT-1, Neuropoietin (NP), and IL-27. CD130 participates in the JAK-STAT signaling pathway and is expressed on T cells, activated B cells, monocytes, plasma cells, and endothelial or epithelial cells.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: GP130 (23-619aa) recombinant protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nProduct Citations: Silvin A, et al. 2020. Cell. 182:1401. PubMed Siepe DH, et al. 2022. Elife. 11:. PubMed Nunes-Santos CJ, et al. 2023. Nat Commun. 14:3708. PubMed Moya-Jódar M, et al. 2023. Stem Cell Reports. 18:64. PubMed Baryawno N et al. 2019. Cell. 177(7):1915-1932 . PubMed Saga R, et al. 2019. Oncol Lett. 17:3555. PubMed Wilmes S, et al. 2021. Elife. 10:. PubMed Hara T, et al. 2021. Cancer Cell. 39(6):779-792.e11. PubMed\u003cbr\u003e\nRRID: AB_2563403 (BioLegend Cat. No. 362005) AB_2563404 (BioLegend Cat. No. 362006)\u003cbr\u003e\nStructure: 130 kD type I transmembrane glycoprotein.\u003cbr\u003e\nDistribution: T cells, activated B cells, monocytes, plasma cells, endothelial cells and epithelial cells.\u003cbr\u003e\nFunction: Common β subunit of IL-6 receptor family, plays a role in signal transduction.\u003cbr\u003e\nLigand\/Receptor: IL-6, IL-11, OSM, CNTF, CT-1, NP, IL-27.\u003cbr\u003e\nCell Type: B cells, Endothelial cells, Epithelial cells, Monocytes, Plasma cells, T cells\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Arzt E, et al. 2001. J. Clin. Invest. 108:1729. 2. Bravo J, et al. 2000. EMBO J. 19:2399. 3. Wang XJ, et al. 1998. Blood 91:3308. 4. Hibi. M, et al. 1990. Cell. 63:1149. 5. Schlossman S, et al. 1995. ed. Leukocyte Typing V. New York. Oxford University Press.\u003cbr\u003e\nGene ID: 3572\u003cbr\u003e\nUniProt: View information about CD130 on UniProt.org\u003cbr\u003e\nClone: 2E1B02\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: GP130, GP-130, IL6ST, IL-6Rβ, Oncostatin M Receptor, Oncostatin-M receptor subunit alpha\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864367911081,"sku":"362005","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-362005","provider":"Iright","version":"1.0","type":"link"}