{"product_id":"biolegend-362907","title":"Biolegend, 362907, APC anti-human CD191 (CCR1) Antibody, 25tests","description":"\u003cp\u003eCD191, also known as CCR1, is a 41 kD, G-protein coupled receptor expressed predominantly by monocytes. CCR1 is also expressed by a subset of T cells and eosinophils. CCR1 positive cells can migrate in response to a CCL3 and CCL5 gradient. CCR1 knock-out studies suggest that this molecule plays an important role in inflammation and susceptibility to viruses and parasites.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human CCR1 transfected cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nProduct Citations: Tian L, et al. 2022. Nat Cancer. 3:1318. PubMed Hinks TSC, et al. 2019. Cell Rep. 28:3249. PubMed Liao Y, et al. 2018. Stem Cells Transl Med. 0.659722222. PubMed Yin S, et al. 2015. Sci Rep. 5: 14432. PubMed Berry MR et al. 2017. Cell. 170(5):860-874 . PubMed\u003cbr\u003e\nRRID: AB_2563918 (BioLegend Cat. No. 362907) AB_2563919 (BioLegend Cat. No. 362908)\u003cbr\u003e\nStructure: G-protein coupled receptor, seven transmembrane protein, 41 kD\u003cbr\u003e\nDistribution: Monocytes, macrophages, subset of T cells, eosinophils\u003cbr\u003e\nFunction: Regulates migration of cells in response to CCL3 and CCL5\u003cbr\u003e\nLigand\/Receptor: CCL3 and CCL5\u003cbr\u003e\nCell Type: Eosinophils, Macrophages, Monocytes, T cells\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors, GPCR\u003cbr\u003e\nAntigen References: 1. Su SB, et al. 1996. J. Leuko. Biol. 60:658. 2. Su S, et al. 1997. Blood. 90:605. 3. Ayehunie S, et al. 1997. Blood. 90:1379. 4. Gerard C, et al. 1997. J. Clin. Invest. 100:2022. 5. Tiffany HL, et al. 1998. J. Immunol. 160:1385. 6. Gilliland CT, et al. 2013. J. Biol. Chem. 288:32194. 7. Bednar F, et al. 2014. J. Immunol. 192:5305.\u003cbr\u003e\nGene ID: 1230\u003cbr\u003e\nUniProt: View information about CD191 on UniProt.org\u003cbr\u003e\nClone: 5F10B29\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CKR1, CD191, HM145, SCYAR1, CMKRB1\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864374792361,"sku":"362907","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-362907","provider":"Iright","version":"1.0","type":"link"}