{"product_id":"biolegend-365824","title":"Biolegend, 365824, PE\/Dazzle™ 594 anti-human CD198 (CCR8) Antibody, 100tests","description":"\u003cp\u003eCCR8, also known as ChemR1, TER1, and CKR-L1, belongs to the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. CCR8 is expressed on some subsets of T cells, monocytes, macrophages, eosinophils, thymocytes, Langerhans cells, neurons, and vascular smooth muscle cells. Binding with its ligand CCL1, CCR8 plays a role in the regulation of monocyte chemotaxis and thymic cell apoptosis. It has been reported that CCR8 is also a receptor for CCL18. CCR8 is also believed to be an alternative coreceptor to CD4 for HIV-1 infection.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Human CCR8-transfected cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE\/Dazzle™ 594 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. * PE\/Dazzle™ 594 has a maximum excitation of 566 nm and a maximum emission of 610 nm.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Clone S19016H induces complement-dependent cytotoxicity (CDC) and antibody-dependent cellular phagocytosis (ADCP) on CCR8-transfected cells.\u003cbr\u003e\nRRID: AB_3716977 (BioLegend Cat. No. 365823) AB_3716977 (BioLegend Cat. No. 365824)\u003cbr\u003e\nStructure: Seven hydrophobic transmembrane domains\u003cbr\u003e\nDistribution: Vascular smooth muscle cells, macrophages, eosinophils, peritoneal macrophages, thymocytes, T cells, Langerhans cells and neurons\u003cbr\u003e\nCell Type: Tregs\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors\u003cbr\u003e\nAntigen References: Tiffany HL, et al. 1997. J Exp Med. 186:165-70. Goya I, et al. 1998. J Immunol. 160:1975-81. Lee S, et al. 2000. J Virol. 74:6946-52. Chensue SW, et al. 2001. J Exp Med. 193:573-84. Qu C, et al. 2004. J Exp Med. 200:1231-41. Isolam SA, et al. 2013. J Exp Med. 210:1889-98.\u003cbr\u003e\nGene ID: 1237\u003cbr\u003e\nUniProt: View information about CD198 on UniProt.org\u003cbr\u003e\nClone: S19016H\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CC-CKR-8, C-C CKR-8, CCR-8, CC chemokine receptor 8, CDw198, CDw198 antigen, CD198, chemokine (C-C motif) receptor 8, chemokine (C-C) receptor 8, TER1, ChemR1, and CKR-L1\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866260132009,"sku":"365824","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-365824","provider":"Iright","version":"1.0","type":"link"}