{"product_id":"biolegend-366404","title":"Biolegend, 366404, PE anti-human Dopamine Receptor D1 Antibody, 100tests","description":"\u003cp\u003eDopamine receptors are a family of G protein-coupled receptors, which is composed of at least five (D1-D5) members. The D1 subtype is the most common receptor in the central nervous system. It is primarily expressed in caudate putamen in humans. This receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. It plays a role in neuronal growth and development along with behavioral responses. The D1 receptor also modulates D2-mediated events. There are two variants of this gene due to alternate transcription initiation sites.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human DRD1-transfectants.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nProduct Citations: Gao A, et al. 2023. J Pharmacol Exp Ther. . PubMed Bellon A, et al. 2019. Front Mol Neurosci. 11:323. PubMed\u003cbr\u003e\nRRID: AB_2565470 (BioLegend Cat. No. 366404)\u003cbr\u003e\nStructure: G protein-coupled receptor.\u003cbr\u003e\nDistribution: DRD1 Transfected cells.\u003cbr\u003e\nFunction: Stimulate adenylyl cyclase and activate cyclic AMP-dependent protein kinases.\u003cbr\u003e\nLigand\/Receptor: Dopamine.\u003cbr\u003e\nCell Type: Dopaminergic Neurons\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers, Synaptic Biology\u003cbr\u003e\nMolecular Family: CD Molecules, GPCR, Postsynaptic proteins\u003cbr\u003e\nAntigen References: 1. Fresnoza S, et al. 2014. J. Neurosci. 34(7):2744. 2. Mizuta K, et al. 2013. Respir. Res. 14:89. 3. Zhu F, et al. 2013. PLoS One 8(8):e70805. 4. Levy F, et al. 2013. J. Child Adolesc. Psychopharmacol. 6:423.\u003cbr\u003e\nGene ID: 1812\u003cbr\u003e\nUniProt: View information about Dopamine Receptor D1 on UniProt.org\u003cbr\u003e\nClone: L205G1\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: DADR, DRD1A, DRD1\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866119164073,"sku":"366404","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-366404","provider":"Iright","version":"1.0","type":"link"}