{"product_id":"biolegend-367102","title":"Biolegend, 367102, Purified anti-human CD14 Antibody, 100μg","description":"\u003cp\u003eCD14 is a 53-55 kD glycosylphosphatidylinositol (GPI)-linked membrane glycoprotein that is also known as the LPS receptor. CD14 is expressed at high levels on monocytes and macrophages, and at lower levels on granulocytes. Some dendritic cell populations such as interfollicular dendritic cells, reticular dendritic cells, and Langerhans cells have also been reported to express CD14. As a high-affinity receptor for LPS, CD14 is involved in the clearance of gram-negative pathogens and in the upregulation of adhesion molecules and cytokine expression in monocytes and neutrophils.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Purified human peripheral blood monocytes.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Fridlender ZG, et al. 1999. Hum. Immunol. 11:1028. Devitt A, et al. 1998. Nature 6675:505.\u003cbr\u003e\nProduct Citations: Huang L, et al. 2020. JCI Insight. 5:00. PubMed Mann ER, et al. 2020. Sci Immunol. :5. PubMed Heesters BA, et al. 2021. J Exp Med. 218:. PubMed Priyanto H, et al. 2021. J Clin Tuberc Other Mycobact Dis. 22:100214. PubMed Bashth OS, et al. 2020. Biomater Sci. 4.128472222. PubMed Ferdosi SR, et al. 2019. Nat Commun. 1.695833333. PubMed Azari S, et al. 2021. MBio. 12:e0184921. PubMed O'Boyle KC, et al. 2020. Methods Mol Biol. 2111:1. PubMed Farhadian SF, et al. 2022. JCI Insight. 7:. PubMed Boulanger MD, et al. 2022. PLoS One. 17:e0269316. PubMed Chen W, Pilling D, and Gomer R 2017. BMC Immunol. . 10.1186\/s12865-017-0230-z. PubMed\u003cbr\u003e\nRRID: AB_2565627 (BioLegend Cat. No. 367101) AB_2565628 (BioLegend Cat. No. 367102)\u003cbr\u003e\nStructure: GPI-linked membrane glycoprotein.\u003cbr\u003e\nDistribution: Monocytes, macrophages, dendritic cells, and granulocytes.\u003cbr\u003e\nFunction: LPS receptor, clearance of Gram-negative pathogens.\u003cbr\u003e\nInteraction: LPS.\u003cbr\u003e\nLigand\/Receptor: LPS.\u003cbr\u003e\nCell Type: Dendritic cells, Granulocytes, Macrophages, Monocytes, Neutrophils\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Neuroinflammation, Neuroscience\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: Stocks SC, et al. 1990. Biochem. J. 268:275. Wright SD, et al. 1990. Science 4975:1431.\u003cbr\u003e\nGene ID: 929\u003cbr\u003e\nUniProt: View information about CD14 on UniProt.org\u003cbr\u003e\nClone: 63D3\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Monocyte differentiation antigen CD14, myeloid cell-specific leucine-rich glycoprotein, LPS receptor\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862467727529,"sku":"367102","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-367102","provider":"Iright","version":"1.0","type":"link"}