{"product_id":"biolegend-368408","title":"Biolegend, 368408, Alexa Fluor® 488 anti-human Ikaros Antibody, 100tests","description":"\u003cp\u003eIkaros, also known as IKZF1, belongs to a family of zinc-finger DNA-binding proteins that regulate lymphocyte differentiation. It has the ability to form homo- and heterodimers with other members of the Ikaros family, which include Aiolos and Helios. Ikaros can be found on a majority of fetal and adult hematopoietic cell types such as T- and B-cells, natural killer cells (NKs), monocytes\/macrophages, and dendritic cells. Ikaros is a tumor suppressor and its absence or reduced expression has been reported in several leukemias.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human Ikaros peptide (431-477 aa) conjugated to KLH Freund's adjuvant.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: ICFC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by intracellular flow cytometry using our True-Nuclear™ Transcription Factor Staining Protocol. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)\u003cbr\u003e\nApplication Notes: There are eight splicing variants with predicted MW 58, 53, 48(2), 43, 41, 31, 24 KDa. This antibody might recognize some of the isoforms.\u003cbr\u003e\nRRID: AB_2616808 (BioLegend Cat. No. 368408)\u003cbr\u003e\nStructure: Zinc-finger DNA binding protein, homo\/heterodimer, 57.5 kD\u003cbr\u003e\nDistribution: Fetal and adult hematopoietic cells.\u003cbr\u003e\nFunction: Regulates lymphocyte differentiation.\u003cbr\u003e\nInteraction: DNA.\u003cbr\u003e\nCell Type: B cells, Dendritic cells\u003cbr\u003e\nBiology Area: Cell Biology, Chromatin Remodeling\/Epigenetics, Immunology, Signal Transduction, Transcription Factors\u003cbr\u003e\nMolecular Family: Nuclear Markers\u003cbr\u003e\nAntigen References: 1. Wargnier A, et al. 1995. Proc. Natl. Acad. Sci. USA 92:6930. 2. Tonnelle C, et al. 2009. Mol. Immunol. 46:1736. 3. Wang H, et al. 2014. Pediatr. Blood Cancer 61:2230.\u003cbr\u003e\nGene ID: 10320\u003cbr\u003e\nUniProt: View information about Ikaros on UniProt.org\u003cbr\u003e\nClone: 16B5C71\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: IK1, IKZF1\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864359620777,"sku":"368408","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-368408","provider":"Iright","version":"1.0","type":"link"}