{"product_id":"biolegend-369701","title":"Biolegend, 369701, Purified anti-human Arginase I Antibody, 25μg","description":"\u003cp\u003eArginase I, also known as ARG1, is a 34.7kD protein expressed by neutrophils and myeloid-derived suppressor cells (MDSCs). There are two isoforms that are differentiated based on their tissue distribution and subcellular localization. Arginase I converts L-arginine into L-ornithine and urea; it is the final enzyme in the urea cycle. While mostly found in the liver, it can also be expressed in cells lacking a comprehensive urea cycle. Also, it contributes to vasodilation and vascular function. Arginase I is also reported to be involved in MDSC mediated suppression of T cell proliferation.  Arginase I has been implicated in hyperargininemia (decreased function of arginase I) and Q fever.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Full length recombinant protein expressed in E.coli.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: ICFC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nProduct Citations: Tinoco R, et al. 2018. J Immunol. 2690:200. PubMed Dinh HQ, et al. 2020. Immunity. 53(2):319-334.e6. PubMed\u003cbr\u003e\nRRID: AB_2571897 (BioLegend Cat. No. 369701) AB_2571898 (BioLegend Cat. No. 369702)\u003cbr\u003e\nStructure: Belongs to the ureohydrolase family and has a molecular mass of 34.7 kD.\u003cbr\u003e\nDistribution: Neutrophils and myeloid-derived suppressor cells (MDSC).\u003cbr\u003e\nFunction: Converts L-arginine into L-ornithine and urea.\u003cbr\u003e\nInteraction: Arginine.\u003cbr\u003e\nCell Type: Neutrophils\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Neuroinflammation, Neuroscience\u003cbr\u003e\nMolecular Family: Enzymes and Regulators\u003cbr\u003e\nAntigen References: 1. Munder M, et al. 2005. Blood 105:2549.2. Luckner-Minden C, et al. 2010. JLB. 87:1125.3. Holowatz L, et al. 2006. Journal of Physiology 574:573.4. Sin YY, et al. 2013. PLoS One 8:11.5. Benoit M, et al. 2008. Eur. J. Immunol. 4:1065.\u003cbr\u003e\nGene ID: 383\u003cbr\u003e\nUniProt: View information about Arginase I on UniProt.org\u003cbr\u003e\nClone: 14D2C43\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: ARG1, Liver Arginase, Type 1 Arginase, Arginase-1, Liver-Type Arginase\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864349921449,"sku":"369701","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-369701","provider":"Iright","version":"1.0","type":"link"}