{"product_id":"biolegend-371202","title":"Biolegend, 371202, Purified anti-human CD357 (GITR) Antibody, 100μg","description":"\u003cp\u003eGITR (glucocorticoid-induced TNF receptor family-regulated gene) is a 25 kD TNF receptor superfamily member (also known as AITR and TNFRSF18). GITR is expressed on activated lymphocytes and is upregulated by T cell receptor engagement. The cytoplasmic domain of GITR is homologous to CD40, 4-1BB and CD27 and has been shown to interact with TRAF 1-3, but not TRAF 5 or 6. GITR signaling has been shown to regulate T cell proliferation and TCR-mediated apoptosis, and to break immunological self-tolerance. GITR binds GITRL and is involved in the development of regulatory T cells and to regulate the activity of Th1 subsets.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant human GITR-Fc chimera\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nProduct Citations: Tavazoie MF, et al. 2018. Cell. 172:825. PubMed Thrash EM, et al. 2020. STAR Protoc. 1:100055. PubMed\u003cbr\u003e\nRRID: AB_2572031 (BioLegend Cat. No. 371202)\u003cbr\u003e\nStructure: TNFR superfamily, 234-amino acid type I transmembrane protein, 25 kD.\u003cbr\u003e\nDistribution: Activated lymphocytes.\u003cbr\u003e\nFunction: Interacts with TRAF's 1-3, but not TRAF 5 or 6, mediates NF-κB activation through the TRAF2\/NIK pathway.\u003cbr\u003e\nLigand\/Receptor: GITRL\u003cbr\u003e\nCell Type: Lymphocytes, Tregs\u003cbr\u003e\nBiology Area: Costimulatory Molecules, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. van der Werf N, et al. 2011. J. Immunol. 187:1411. 2. Shimizu J, et al. 2002. Nat. Immunol. 3:135. 3. McHugh RS, et al. 2002. Immunity 16:311. 4. Kwon B, et al. 1999. J. Biol. Chem. 274:6056.\u003cbr\u003e\nGene ID: 8784\u003cbr\u003e\nUniProt: View information about CD357 on UniProt.org\u003cbr\u003e\nClone: 108-17\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: TNFRSF18, Activation-inducible TNFR, AITR, Glucocorticoid-inducible TNFR\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860776898729,"sku":"371202","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-371202","provider":"Iright","version":"1.0","type":"link"}