{"product_id":"biolegend-372008","title":"Biolegend, 372008, FITC anti-human CLEC1B (CLEC2) Antibody, 100tests","description":"\u003cp\u003eC-type lectin domain family 1 member B (CLEC1B, CLEC2) is a 32kD, type II transmembrane protein, highly expressed on platelets and megakaryocytes. CLEC1B is involved in platelet activation and aggregation, and mediates the capture of HIV-1 by platelets. CLEC1B contains one hem-immunoreceptor tyrosine-based activation motif (hemITAM) though which interact with Syk and PLC-g. The known ligands of CLEC1B are rhodocytin and podoplanin.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Extracellular region of CLEC1B (amino acids 68-229).\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with FITC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: immunoprecipitation; inhibition of podoplanin and rhodocytin-mediated platelet activation.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Gitz E, et al. 2014. Blood 124:2262.\u003cbr\u003e\nProduct Citations: Bredemeyer AL, et al. 2022. Development. :149. PubMed\u003cbr\u003e\nRRID: AB_2650868 (BioLegend Cat. No. 372007) AB_2650869 (BioLegend Cat. No. 372008)\u003cbr\u003e\nStructure: Type II transmembrane protein, 32 kD, homodimer, 1 hemITAM motif.\u003cbr\u003e\nDistribution: Platelets, megakaryocytes; low expression on myeloid cells.\u003cbr\u003e\nFunction: Mediates platelet activation and aggregation; facilitates capture of HIV by platelets.\u003cbr\u003e\nInteraction: Syk, PLC-g.\u003cbr\u003e\nLigand\/Receptor: Rhodocytin, podoplanin.\u003cbr\u003e\nCell Type: Dendritic cells, Megakaryocytes, Platelets\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nAntigen References: 1. Manne BK, et al. 2015. J. Biol. Chem. 290:11557. 2. Hughes CE, et al. 2013. J. Biol. Chem. 288:5127. 3. Parguiña AF, et al. 2012. Blood 120:e117-26. 4. Osada M, et al. 2012. J. Biol. Chem. 287:22241.\u003cbr\u003e\nGene ID: 51266\u003cbr\u003e\nUniProt: View information about CLEC1B on UniProt.org\u003cbr\u003e\nClone: AYP1\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: C-type lectin domain family 1 member B, CLEC2B, PRO1384, QDED721\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862546108585,"sku":"372008","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-372008","provider":"Iright","version":"1.0","type":"link"}