{"product_id":"biolegend-374210","title":"Biolegend, 374210, PE\/Cyanine7 anti-human CD86 Antibody, 100tests","description":"\u003cp\u003eCD86 is an 80 kD immunoglobulin superfamily member also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, monocytes\/macrophages, dendritic cells, and astrocytes. CD86, along with CD80, is the ligand of CD28 and CD152 (CTLA-4). CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce costimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can bind to CD152 as well, also known as CTLA-4, to deliver an inhibitory signal to T cells.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: ARH 77 (B lymphoblastoid cell line).\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE\/Cyanine7 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nProduct Citations: Wang X, et al. 2023. Stem Cell Rev Rep. . PubMed Wu L, et al. 2023. Cell Res. . PubMed Sefik E, et al. 2022. Nature. 606:585. PubMed Bergamaschi L, et al. 2021. Immunity. 54(6):1257-1275.e8. PubMed Lee S, et al. 2021. Nature. 599:283. PubMed Sefik E, et al. 2021. Nat Biotechnol. . PubMed Paulikat AD, et al. 2022. J Innate Immun. 14:569. PubMed Han P, et al. 2020. Sci Adv. 6:eaaz1580. PubMed\u003cbr\u003e\nRRID: AB_2728391 (BioLegend Cat. No. 374209) AB_2728392 (BioLegend Cat. No. 374210)\u003cbr\u003e\nStructure: Ig superfamily, single-chain transmembrane glycoprotein, 80 kD\u003cbr\u003e\nDistribution: Monocytes\/macrophages, activated B cells and T cells, dendritic cells\u003cbr\u003e\nFunction: T Cell activation\u003cbr\u003e\nInteraction: C-Jun, NFκB\u003cbr\u003e\nLigand\/Receptor: CD28, CD152\u003cbr\u003e\nCell Type: B cells, Dendritic cells, Macrophages, Monocytes, T cells\u003cbr\u003e\nBiology Area: Cell Biology, Costimulatory Molecules, Immunology, Neuroscience, Neuroscience Cell Markers\u003cbr\u003e\nMolecular Family: CD Molecules, Immune Checkpoint Receptors\u003cbr\u003e\nAntigen References: 1. Hathcock K, et al. 1996. Adv. Immunol. 62:131. 2. June C, et al. 1994. Immunol. Today 15:321.\u003cbr\u003e\nGene ID: 942\u003cbr\u003e\nUniProt: View information about CD86 on UniProt.org\u003cbr\u003e\nClone: BU63\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nWorkshop: HCDM listed\u003cbr\u003e\nOther Names: B7-2, B70, Ly-58\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862925267113,"sku":"374210","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-374210","provider":"Iright","version":"1.0","type":"link"}