{"product_id":"biolegend-375025","title":"Biolegend, 375025, PE\/Cyanine7 anti-human CD159c (NKG2C) Antibody, 25tests","description":"\u003cp\u003eCD159c, also known as NKG2C or KLRC2, is a type II transmembrane protein. It belongs to the killer cell lectin-like receptor family also known as the NKG2 family. It is expressed on NK and NKT cells and T cell subsets. NKG2C is an activating NK cell receptor and it is expressed as a heterodimer with CD94. In humans, the NKG2C\/CD94 complex interacts with HLA-E on target cells and delivers activating signals through immunoreceptor tyrosine-based activation motifs.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human NKG2C\/CD94-transfectants\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE\/Cyanine7 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool).\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: S19005E does not crossreact with mouse CD159c.\u003cbr\u003e\nRRID: AB_3720520 (BioLegend Cat. No. 375025) AB_3720520 (BioLegend Cat. No. 375026)\u003cbr\u003e\nStructure: Type II transmembrane proteins of the C-type lectin superfamily\u003cbr\u003e\nDistribution: NK cells, NKT cells, T cell subsets\u003cbr\u003e\nFunction: Activating NK cell receptor\u003cbr\u003e\nLigand\/Receptor: HLA-E\u003cbr\u003e\nCell Type: Lymphocytes, NK cells, NKT cells, T cells\u003cbr\u003e\nBiology Area: Immuno-Oncology, Immunology\u003cbr\u003e\nMolecular Family: Immune Checkpoint Receptors\u003cbr\u003e\nAntigen References: Malisheni M, et al. 2017. Front Immunol. 8:863. Sáez-Borderías A, et al. 2009. J Immunol, 182:829. Kamiya T, et al. 2019. J. Clin. Invest. 129:2094.\u003cbr\u003e\nGene ID: 3822\u003cbr\u003e\nUniProt: View information about CD159c on UniProt.org\u003cbr\u003e\nClone: S19005E\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Killer Cell Lectin Like Receptor C2, KLRC2, NK Cell Receptor C\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866257969321,"sku":"375025","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-375025","provider":"Iright","version":"1.0","type":"link"}