{"product_id":"biolegend-375137","title":"Biolegend, 375137, Brilliant Violet 785™ anti-human CD159a (NKG2A) Antibody, 25tests","description":"\u003cp\u003eCD159a, also known as NKG2A or KLRC1, is a type II transmembrane protein. It belongs to the killer cell lectin-like receptor family also known as the NKG2 family. It is expressed on NK and NKT cells and T cell subsets. NKG2A is an inhibitory NK cell receptor and it is expressed as a heterodimer with CD94. In human, NKG2A\/CD94 complex interacts HLA-E on target cells and inhibits T cells and NK cell effector functions. Recent studies showed that NKG2A blockade enhances the anti-tumor effect of NK cell and CD8 + T cells.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human NKG2A\/CD94-transfectants\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 785™ under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. Brilliant Violet 785™ excites at 405 nm and emits at 785 nm. The bandpass filter 780\/60 nm is recommended for detection, although filter optimization may be required depending on other fluorophores used. Be sure to verify that your cytometer configuration and software setup are appropriate for detecting this channel. Refer to your instrument manual or manufacturer for support. Brilliant Violet 785™ is a trademark of Sirigen Group Ltd. Learn more about Brilliant Violet™. This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.\u003cbr\u003e\nExcitation Laser: Violet Laser (405 nm)\u003cbr\u003e\nApplication Notes: Clone S19004C does not cross-react with mouse CD159a.\u003cbr\u003e\nRRID: AB_3068113 (BioLegend Cat. No. 375137) AB_3068113 (BioLegend Cat. No. 375138)\u003cbr\u003e\nStructure: Type II transmembrane proteins of the C-type lectin superfamily\u003cbr\u003e\nDistribution: NK cells, NKT cells, T cell subsets\u003cbr\u003e\nFunction: Inhibiting NK cell receptor\u003cbr\u003e\nLigand\/Receptor: HLA-E\u003cbr\u003e\nCell Type: Lymphocytes, NK cells, NKT cells, T cells\u003cbr\u003e\nBiology Area: Immuno-Oncology, Immunology\u003cbr\u003e\nMolecular Family: Immune Checkpoint Receptors\u003cbr\u003e\nAntigen References: Brooks AG, et al. 1999. J Immunol. 162:305-13. Kaiser BK, et al. 2008. Proc Natl Acad Sci U S A. 105: 6696-701. Braud VM, et al. 2003. Trends Immunol. 24:162-4. Kamiya T, et al. 2019. J Clin Invest. 129:2094. André P, et al. 2018. Cell. 175:1731.\u003cbr\u003e\nGene ID: 3821\u003cbr\u003e\nUniProt: View information about CD159a on UniProt.org\u003cbr\u003e\nClone: S19004C\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Killer Cell Lectin Like Receptor C1, KLRC1, NK Cell Receptor A\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866257445033,"sku":"375137","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-375137","provider":"Iright","version":"1.0","type":"link"}