{"product_id":"biolegend-376004","title":"Biolegend, 376004, PE anti-human CD59 Recombinant Antibody, 100tests","description":"\u003cp\u003eCD59 is a 19-25 kD glycosylphosphatidylinositol (GPI)-anchored glycoprotein also known as protectin, MACIF, and H19. It is broadly expressed on hematopoietic and non-hematopoietic cells. CD59 inhibits the cytolytic activity of complement by binding to C9, inhibiting incorporation into C5b-8, and preventing the terminal steps in complement polymerization of the membrane attack complex. CD59 has also been reported to play a role in T cell activation.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Recombinant\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nProduct Citations: Tschongov T, et al. 2024. Front Immunol. 1383123:15. PubMed\u003cbr\u003e\nRRID: AB_2892458 (BioLegend Cat. No. 376003) AB_2892458 (BioLegend Cat. No. 376004)\u003cbr\u003e\nStructure: Ly6 superfamily, single chain GPI-linked membrane protein, 19-25 kD\u003cbr\u003e\nDistribution: All cell types\u003cbr\u003e\nFunction: Blocks complement-mediated lysis by inhibiting MAC formation\u003cbr\u003e\nLigand\/Receptor: Complement components C8, C9\u003cbr\u003e\nBiology Area: Cell Biology, Costimulatory Molecules, Immunology, Neuroinflammation, Neuroscience\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Huang Y, et al. 2006. J. Biol. Chem. 281(37):27398-27404.\u003cbr\u003e\nGene ID: 966\u003cbr\u003e\nUniProt: View information about CD59 on UniProt.org\u003cbr\u003e\nClone: QA19A13\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Protectin, H19, 1F-5Ag, HRF20, MACIF, MIRL, P-18\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866186371241,"sku":"376004","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-376004","provider":"Iright","version":"1.0","type":"link"}