{"product_id":"biolegend-381010","title":"Biolegend, 381010, PE anti-human CD86 Antibody, 100tests","description":"\u003cp\u003eCD86, also known as B7-2, B70, and Ly-58, is an 80 kD immunoglobulin superfamily member. CD86 is expressed on activated B and T cells, monocytes\/macrophages, dendritic cells, and astrocytes. CD86, along with CD80, is the ligand of CD28 and CD152 (CTLA-4). CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce costimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: hCD86 Recombinant protein (full)\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nRRID: AB_3083375 (BioLegend Cat. No. 381009) AB_3083375 (BioLegend Cat. No. 381010)\u003cbr\u003e\nStructure: Ig superfamily, single-chain transmembrane glycoprotein, 80 kD\u003cbr\u003e\nDistribution: Monocytes\/macrophages, activated B cells and T cells, dendritic cells\u003cbr\u003e\nFunction: T Cell activation\u003cbr\u003e\nInteraction: C-Jun, NFκB\u003cbr\u003e\nLigand\/Receptor: CD28, CD152\u003cbr\u003e\nCell Type: B cells, Dendritic cells, Macrophages, Monocytes, T cells\u003cbr\u003e\nBiology Area: Cell Biology, Costimulatory Molecules, Immunology, Neuroscience, Neuroscience Cell Markers\u003cbr\u003e\nMolecular Family: CD Molecules, Immune Checkpoint Receptors\u003cbr\u003e\nAntigen References: Hathcock KS, et al. 1996. Adv Immunol. 62:131-66. June CH, et al. 1994. Immunol Today. 15:321-31.\u003cbr\u003e\nGene ID: 942\u003cbr\u003e\nUniProt: View information about CD86 on UniProt.org\u003cbr\u003e\nClone: W17233E\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: B7-2, B70, Ly-58\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866317574313,"sku":"381010","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-381010","provider":"Iright","version":"1.0","type":"link"}