{"product_id":"biolegend-385402","title":"Biolegend, 385402, Purified anti-human CD152 (CTLA-4) Recombinant Antibody, 100μg","description":"\u003cp\u003eCD152, also known as Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4), is a 33 kD member of the immunoglobulin superfamily. It is transiently expressed on activated T cells. CTLA-4 is expressed on the surface of helper T cells and transmits an inhibitory signal to T cells. Regulatory T cells express high levels of CTLA-4. CTLA-4  is similar to CD28 in amino acid sequence, structure, and genomic organization. Whereas CD28 delivers a costimulatory signal in T cell activation, CTLA-4 negatively regulates cell-mediated immune responses through interaction with CD80 (B7-1) and CD86 (B7-2) present on antigen presenting cells (APC). CTLA-4 is thought to play a role in the induction and maintenance of immunological tolerance as well as the development of protective immunity and thymocyte regulation.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Recombinant\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: ICFC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Clone QA20B10 can completely block the binding of parental clone to target cells.\u003cbr\u003e\nRRID: AB_2936635 (BioLegend Cat. No. 385402)\u003cbr\u003e\nStructure: Ig superfamily and 33 kD\u003cbr\u003e\nDistribution: Activated T cells and B cells\u003cbr\u003e\nFunction: Negative regulator of T cell activation\u003cbr\u003e\nInteraction: Antigen presenting cells\u003cbr\u003e\nLigand\/Receptor: B7-1 (CD80), B7-2 (CD86)\u003cbr\u003e\nAntigen References: Kuiper HM, et al. 1995. J Immunol. 155:1776-83. Pistillo MP, et al. 2003. Blood. 101:202-9. Tan PH, et al. 2005. Blood. 106:2936-43. Steiner K, et al. 2001. Clin Exp Immunol. 126:143-50.\u003cbr\u003e\nGene ID: 1493\u003cbr\u003e\nUniProt: View information about CD152 on UniProt.org\u003cbr\u003e\nClone: QA20B10\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CTLA4, Cytotoxic T-Lymphocyte Antigen 4, CTLA-4\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866194759849,"sku":"385402","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-385402","provider":"Iright","version":"1.0","type":"link"}