{"product_id":"biolegend-385913","title":"Biolegend, 385913, APC\/Fire™ 750 anti-human IL-17A Recombinant Antibody, 25tests","description":"\u003cp\u003eIL-17A is the founding member of the IL-17 family, a group of six structurally related pro-inflammatory cytokines. IL-17A is the signature cytokine of Th17 subpopulation of CD4+ T cells. Neutrophils are also a major source of IL-17A. IL-17A can elicit multiple biological activities on a variety of cells. For instance, IL-17A can induce IL-6, IL-8, G-CSF, and PGE2 production from epithelial cells, endothelial cells, or fibroblast. IL-17A also further regulates neutrophil functions. Human IL-17A shares 63%, 63% and 72% amino acid sequence similarity to rat IL-17A, mouse IL-17A, and a protein encoded by the ORF13 gene of herpesvirus Saimiri (HVS) respectively.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Recombinant\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC\/Fire™ 750 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: ICFC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. * APC\/Fire™ 750 has a maximum excitation of 650 nm and a maximum emission of 774 nm.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication Notes: Clone QA18A46 can completely block the binding of clone BL168 on target cells.\u003cbr\u003e\nRRID: AB_3720542 (BioLegend Cat. No. 385913) AB_3720542 (BioLegend Cat. No. 385914)\u003cbr\u003e\nStructure: ~15 kD cytokine\u003cbr\u003e\nDistribution: Activated T cells, neutrophils\u003cbr\u003e\nFunction: Proinflammatory cytokine\u003cbr\u003e\nLigand\/Receptor: IL-17A receptor\u003cbr\u003e\nCell Type: Lymphocytes, Neutrophils, T cells, Th17\u003cbr\u003e\nBiology Area: Adaptive Immunity, Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: Cytokines\/Chemokines\u003cbr\u003e\nAntigen References: Spriggs MK. 1997. J Clin Immunol. 17:366-9. Kawaguchi M, et al. 2004. J Allergy Clin Immunol. 114:1265-73. Furuzawa-Carballeda J, et al. 2007. Autoimmun Rev. 6:169-75.\u003cbr\u003e\nGene ID: 3605\u003cbr\u003e\nUniProt: View information about IL-17A on UniProt.org\u003cbr\u003e\nClone: QA18A46\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Interluekin 17A, IL-17, CTLA8\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866183061673,"sku":"385913","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-385913","provider":"Iright","version":"1.0","type":"link"}