{"product_id":"biolegend-389602","title":"Biolegend, 389602, Purified anti-human CD158k (KIR3DL2) Antibody, 100μg","description":"\u003cp\u003eCD158 molecules, also known as KIRs (killer cell immunoglobulin-like receptors), are a family of transmembrane proteins with either two (KIR2D) or three (KIR3D) Ig-like extracellular domains. Some KIRs with long cytoplasmic domains contain ITIMs and possess inhibitory functions and others with short cytoplasmic region lack ITIM and have activation functions. Fifteen polymorphic KIR genes have been reported in humans. CD158k is a 70 kD three extracellular Ig domain glycoprotein that presents as a disulphide-bonded homodimer extracellularly. The intracellular long cytoplasmic tail of CD158k contains two ITIM domains. It is expressed primarily on a subset of NK cells and a subset of T cells. KIR3DL2 binds to a number of different MHC class I molecules depending on the viral peptide sequence presented.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: KIR3DL2-transfected cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Based on in-house testing on different KIR-expressing transfectants, clone S22025B does not interact with other KIR protein family members.\u003cbr\u003e\nRRID: AB_3662347 (BioLegend Cat. No. 389602)\u003cbr\u003e\nStructure: 70 kD three Ig-like extracellular domain glycoprotein\u003cbr\u003e\nDistribution: Subset of NK cells, subset of T cells\u003cbr\u003e\nFunction: NK Cell regulation\u003cbr\u003e\nLigand\/Receptor: MHC class I molecules\u003cbr\u003e\nCell Type: Lymphocytes, NK cells, T cells\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Colonna M. et al. 1995. Science. 268:405-8. Lanier LL. 2005. Annu Rev Immunol. 23:225-74. Hansasuta P, et al. 2004. Eur J immunol. 34:1673-9.\u003cbr\u003e\nGene ID: 3812\u003cbr\u003e\nUniProt: View information about CD158k on UniProt.org\u003cbr\u003e\nClone: S22025B\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: NKAT4, Killer Cell Immunoglobulin-Like Receptor 3DL2\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866277564585,"sku":"389602","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-389602","provider":"Iright","version":"1.0","type":"link"}