{"product_id":"biolegend-390352","title":"Biolegend, 390352, Purified anti-human CD56 (NCAM) Antibody, 100μg","description":"\u003cp\u003eCD56, also known as NCAM (neural cell adhesion molecule), Leu-19, or NKH1, is a single transmembrane glycoprotein. It is a member of the Ig superfamily. The 140 kD isoform is expressed on NK and NKT cells. CD56 is also expressed in the brain (cerebellum and cortex) and at neuromuscular junctions. Certain large granular lymphocyte (LGL) leukemias, small-cell lung carcinomas, neuronal derived tumors, myelomas, and myeloid leukemias also express CD56. CD56 plays a role in homophilic and heterophilic adhesion via binding to itself or heparan sulfate.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Mammalian-derived recombinant protein aa 20-718\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Flow cytometry testing showed that clone W22098E can block the binding of clones HCD56 and W22097A on target cells. Flow cytometry testing showed that clone W22098E does not affect the binding of clones MEM-188, 5.1H11 and W22098A on target cells.\u003cbr\u003e\nRRID: AB_3662359 (BioLegend Cat. No. 390352)\u003cbr\u003e\nStructure: Ig superfamily, single transmembrane or GPI-anchored glycoprotein\u003cbr\u003e\nDistribution: NK cells, T subset, neural tissue, some LGL and myeloid leukemias\u003cbr\u003e\nFunction: Adhesion\u003cbr\u003e\nLigand\/Receptor: Heparan sulfate\u003cbr\u003e\nCell Type: B cells, Leukemia, Mesenchymal Stem Cells, Neurons, T cells\u003cbr\u003e\nBiology Area: Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Stem Cells, Synaptic Biology\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: Lanier L, et al. 1991. J Immunol. 146:4421-6. Hemperly J, et al. 1990. J Mol Neurosci. 2:71-8. Cremer H, et al. 1994. Nature. 367:455-9.\u003cbr\u003e\nGene ID: 4684\u003cbr\u003e\nUniProt: View information about CD56 on UniProt.org\u003cbr\u003e\nClone: W22098E\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Leu-19, NKH1, NCAM-1\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866433278121,"sku":"390352","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-390352","provider":"Iright","version":"1.0","type":"link"}