{"product_id":"biolegend-390552","title":"Biolegend, 390552, Purified anti-human CD202b (Tie2\/Tek) Antibody, 100μg","description":"\u003cp\u003eCD202b, also known as Tie2 or TEK, is a 145 kD type I transmembrane protein. It is a member of the receptor tyrosine kinase (RTK) family of proteins and is expressed by endothelial cells and their progenitors, quiescent hematopoietic stem cells (HSCs), and a subpopulation of monocytes. Angiopoietin-1 (Ang-1) is an activator of CD202b that promotes, maintains, and stabilizes mature vessels and maintains HSCs in a quiescent state. Ang-2, another ligand of CD202b, is involved in postnatal angiogenesis and in antagonizing the effects of Ang-1. Tie2 binds to Ang-4 as well.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant extracellular domain of human Tie2\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested Direct ELISA - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. Each lot of this antibody is verified by Direct ELISA. The optimal concentration of this reagent for the specific application and the experiment design should be established by the end-user. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Clone A19069E partially blocks the staining of reference clone 33.1 Recombinant protein completely blocks the staining of test clone A19069E.\u003cbr\u003e\nRRID: AB_3675120 (BioLegend Cat. No. 390552)\u003cbr\u003e\nStructure: 145 kD type I transmembrane protein, receptor tyrosine kinase (RTK) family\u003cbr\u003e\nDistribution: Endothelial cells, subsets of hematopoietic stem cells and and a subset of monocytes\u003cbr\u003e\nFunction: Angiogenesis, hematopoiesis, monocytes chemotaxis\u003cbr\u003e\nInteraction: Endothelial cells, hematopoietic stem and progenitors, monocytes\u003cbr\u003e\nLigand\/Receptor: Angiopoietin-1 (Ang-1), Ang-2, and Ang-4\u003cbr\u003e\nCell Type: Endothelial cells, Hematopoietic stem and progenitors, Monocytes\u003cbr\u003e\nBiology Area: Angiogenesis, Cell Biology, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: De Palma M, et al. 2005. Cancer Cell. 8::211-26. Shaw JP, et al. 2004. Blood Cells Mol Dis. 32:168-75. Hsu HC, et al. 2000. Blood. 96:3757-62. Arai F, et al. 2004. Cell. 118:149-61.\u003cbr\u003e\nGene ID: 7010\u003cbr\u003e\nUniProt: View information about CD202b on UniProt.org\u003cbr\u003e\nClone: A19069E\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Angiopoietin-1 receptor, Endothelial tyrosine kinase, Tunica interna endothelial cell kinase, Tyrosine kinase with Ig and EGF homology domains-2, Tyrosine-protein kinase receptor TEK, Tyrosine-protein kinase receptor TIE-2 (hTIE2), p140 TEK, CD202\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866066702505,"sku":"390552","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-390552","provider":"Iright","version":"1.0","type":"link"}