{"product_id":"biolegend-393003","title":"Biolegend, 393003, PE anti-human CD309 (VEGFR2) Antibody, 25tests","description":"\u003cp\u003eCD309, also known as VEGF-R2, KDR, and Flk-1 (mouse), is a type I transmembrane glycoprotein. It is a member of the CSF-1\/PDGF receptor family of type III tyrosine kinase receptors. Human VEGF-R2 is mainly expressed by endothelial cells, embryonic tissues, and megakaryocytes. It plays an important role in the regulation of angiogenesis, vasculogenesis, and vascular permeability. The ligands of VEGF-R2 include VEGF-A, VEGF-C, and VEGF-D splice isoforms. Activation of VEGF-R2 with its ligands results in the receptor dimerization and autophosphorylation, stimulating endothelial cell proliferation and migration.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant Human VEGFR2-Fc Chimera\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: This clone does not cross-react with mouse endothelial cells.\u003cbr\u003e\nProduct Citations: Tian Y, et al. 2022. Cancer Immunol Immunother. 2663:71. PubMed Raggi C, et al. 2022. Curr Protoc. 2:e389. PubMed\u003cbr\u003e\nRRID: AB_2734448 (BioLegend Cat. No. 393003) AB_2734449 (BioLegend Cat. No. 393004)\u003cbr\u003e\nStructure: Type I transmembrane glycoprotein, type III tyrosine kinase receptor, CSF-1\/PDGF receptor family\u003cbr\u003e\nDistribution: Endothelial cells, embryonic tissues\u003cbr\u003e\nFunction: VEGFR2 regulates angiogenesis as well as vascular development and permeability.\u003cbr\u003e\nLigand\/Receptor: VEGF-A, VEGF-C, and VEGF-D splice isoforms\u003cbr\u003e\nCell Type: Endothelial cells\u003cbr\u003e\nBiology Area: Angiogenesis, Cell Biology, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors\u003cbr\u003e\nAntigen References: DiSalvo J, et al. 1995. J Biol Chem. 270:7717. McColl BK, et al. 2003. J Exp Med. 198:863. Albuquerque RJ, et al. 2009. Nat Med. 15:1023. Guangqi E, et al. 2012. J Biol Chem. 287:3029. Koch S, and Claesson-Welsh. 2012. Cold Spring Harb Perspect Med. 2:a006502. Munaut C, et al. 2012. Plos One. 7:e33475. Wehland M, et al. 2013. Int J Mol Sci. 14:9338.\u003cbr\u003e\nGene ID: 3791\u003cbr\u003e\nUniProt: View information about CD309 on UniProt.org\u003cbr\u003e\nClone: A16085H\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: VEGFR2, KDR\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864395403433,"sku":"393003","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-393003","provider":"Iright","version":"1.0","type":"link"}