{"product_id":"biolegend-395515","title":"Biolegend, 395515, APC\/Fire™ 750 anti-human CD288 (TLR8) Antibody, 25tests","description":"\u003cp\u003eToll-like receptor (TLR) 8, also known as CD288, is a 83 kDa, type 1 transmembrane protein, member of the TLR receptor family. TLR8 is expressed intracellulary in monocytes, macrophages and myeloid dendritic cells, and plays an important role in the innate immune response by binding single-stranded RNA (ssRNA). TLR8 triggers anti-viral reponses promoting the secretion of proinflammatory cytokines such as IL-12 and TNF.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human TLR8-transfected cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC\/Fire™ 750 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: ICFC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. * APC\/Fire™ 750 has a maximum excitation of 650 nm and a maximum emission of 774 nm.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nRRID: AB_3097530 (BioLegend Cat. No. 395515) AB_3097530 (BioLegend Cat. No. 395516)\u003cbr\u003e\nStructure: 83 kD, Type 1 transmembrane protein\u003cbr\u003e\nDistribution: Endosomal compartments of monocytes, macrophages, myeloid dendritic cells, and neutrophils\u003cbr\u003e\nFunction: Binds single-stranded RNA\u003cbr\u003e\nInteraction: MYD88, TRAF6, IRAK4\u003cbr\u003e\nLigand\/Receptor: Single-stranded GU-rich RNA\u003cbr\u003e\nCell Type: Dendritic cells, Macrophages, Monocytes, Neutrophils\u003cbr\u003e\nBiology Area: Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: CD Molecules, Toll Like Receptors\u003cbr\u003e\nAntigen References: Lood C, et al. 2017. J Exp Med. 214:2103. Prinz N, et al. 2011. Blood. 118:2322. Gringhuis SI, et al. 2010. Nat Immunol. 11419. Cros J, et al. 2010. Immunity. 33:375. Peng G, et al. 2005. Science. 309:1380.\u003cbr\u003e\nGene ID: 51311\u003cbr\u003e\nUniProt: View information about CD288 on UniProt.org\u003cbr\u003e\nClone: S16018A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CD288, Toll-like receptor 8\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866226839721,"sku":"395515","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-395515","provider":"Iright","version":"1.0","type":"link"}