{"product_id":"biolegend-395708","title":"Biolegend, 395708, Alexa Fluor® 700 anti-human β2-microglobulin Antibody, 100tests","description":"\u003cp\u003eβ2-microglobulin (β2M) is a 12 kD nonpolymorphic Ig like protein. It is a non-membrane-anchored glycoprotein and is noncovalently associated with 39-44 kD polymorphic heavy chains of MHC class I molecules to form HLA class I antigen complex. In association with HLA class I, β2M is expressed on all leukocytes, platelets, endothelial cells, and epithelial cells. β2M plays an essential role both in governing MHC class I molecules stability and in promoting antigen binding and presenting the antigen to CD3\/TCR complex of CD8 + T cells.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant human Beta2-microglobulin\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 700 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood. * Alexa Fluor® 700 has a maximum emission of 719 nm when it is excited at 633 nm \/ 635 nm. Prior to using Alexa Fluor® 700 conjugate for flow cytometric analysis, please verify your flow cytometer's capability of exciting and detecting the fluorochrome. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication Notes: Clone A17082A partially cross-blocks anti-human ß2-microglobulin clone 2M2 and does not block anti-human HLA-A,B,C clone W6\/32 staining, based on in-house testing.\u003cbr\u003e\nProduct Citations: Yeh C, et al. 2024. Nat Immunol. 1943:25. PubMed\u003cbr\u003e\nRRID: AB_2801056 (BioLegend Cat. No. 395707) AB_2801057 (BioLegend Cat. No. 395708)\u003cbr\u003e\nStructure: 12 KD, Ig like structure\u003cbr\u003e\nDistribution: Leukocytes, platelets, endothelial cells, epithelial cells and other nucleated cells.\u003cbr\u003e\nFunction: Form MHC class I\u003cbr\u003e\nInteraction: MHC class I heavy chain and other MHC I like molecules.\u003cbr\u003e\nCell Type: Antigen-presenting cells, Endothelial cells, Epithelial cells, Leukocytes, Platelets\u003cbr\u003e\nBiology Area: Cancer Biomarkers, Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: MHC Antigens\u003cbr\u003e\nAntigen References: Engelhard VH. 1994. Curr. Opin. Immunol. 6:13. Williams DB, et al. 1989. J. Immunol. 142:2796. Danliczyk UG and TL. Delovitch. 1994. J. Immunol. 153:3533. Williams A, et al. 2002. Tissue Antigens. 59:3.\u003cbr\u003e\nGene ID: 567\u003cbr\u003e\nUniProt: View information about beta2-microglobulin on UniProt.org\u003cbr\u003e\nClone: A17082A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: β2M, β2-M, beta2-microglobulin b2-M, b2M\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866049892521,"sku":"395708","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-395708","provider":"Iright","version":"1.0","type":"link"}