{"product_id":"biolegend-397219","title":"Biolegend, 397219, PE\/Dazzle™ 594 anti-human CD38 Antibody, 25tests","description":"\u003cp\u003eCD38 is a 45 kD type II transmembrane glycoprotein also known as T10. It is an ADP-ribosyl hydrolase expressed at variable levels on hematopoietic cells and in some non-hematopoietic tissues (such as brain, muscles, and kidney). In humans, it is expressed at high levels on plasma cells and activated T and B cells. By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, adhesion, and the metabolism of cADPR and NAADP. CD31 is the ligand of CD38.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human CD38 transfectants\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE\/Dazzle™ 594 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. * PE\/Dazzle™ 594 has a maximum excitation of 566 nm and a maximum emission of 610 nm.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: S17015F is able to cross-block binding of clones HIT2 and HB-7 also raised against human CD38, but not S17015A based on in-house testing.\u003cbr\u003e\nRRID: AB_2890837 (BioLegend Cat. No. 397219) AB_2890837 (BioLegend Cat. No. 397220)\u003cbr\u003e\nStructure: ADP-ribosyl cyclase, ectoenzyme, type II glycoprotein, 45 kD\u003cbr\u003e\nDistribution: T cells, B cells, NK, myeloid, plasma, and dendritic cells\u003cbr\u003e\nFunction: Ecto-ADP-ribosyl cyclase, calcium signaling, cell activation\u003cbr\u003e\nLigand\/Receptor: CD31, hyaluronic acid\u003cbr\u003e\nCell Type: B cells, Dendritic cells, NK cells, Plasma cells, T cells\u003cbr\u003e\nBiology Area: Cell Adhesion, Cell Biology, Immunology\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: Ferrero E, et al. 1999. J Leuko Biol. 65:151. Lund F, et al. 1995. Immunol. Today 16:469.\u003cbr\u003e\nGene ID: 952\u003cbr\u003e\nUniProt: View information about CD38 on UniProt.org\u003cbr\u003e\nClone: S17015F\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: HB7, T10, ADP-ribosyl cyclase\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866234474665,"sku":"397219","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-397219","provider":"Iright","version":"1.0","type":"link"}