{"product_id":"biolegend-397509","title":"Biolegend, 397509, Alexa Fluor® 594 anti-human CD44 Antibody, 25μg","description":"\u003cp\u003eCD44 is a 80-95 kD glycoprotein also known as Hermes, Pgp1, H-CAM, or HUTCH. It is expressed on all leukocytes, endothelial cells, hepatocytes, and mesenchymal cells. As B and T cells become activated or progress to the memory stage, CD44 expression increases from low or mid levels to high levels. Thus, CD44 has been reported to be a valuable marker for memory cell subsets. High CD44 expression on Treg cells has been associated with potent suppressive function via high production of IL-10. CD44 is an adhesion molecule involved in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and to the sites of inflammation, and leukocyte aggregation.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 594 under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: IHC-P - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5.0 - 10 µg\/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 594 has an excitation maximum of 590 nm, and a maximum emission of 617 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses\u003cbr\u003e\nProduct Citations: Campisi L, et al. 2022. Nature. 606:945. PubMed\u003cbr\u003e\nRRID: AB_2860987 (BioLegend Cat. No. 397509) AB_2876720 (BioLegend Cat. No. 397510)\u003cbr\u003e\nStructure: Variable splicing of CD44 gene generates many CD44 isoforms, 80-95 kD\u003cbr\u003e\nDistribution: All leukocytes, epithelial cells, endothelial cells, hepatocytes, mesenchymal cells\u003cbr\u003e\nFunction: Leukocyte attachment and rolling on endothelial cells, stromal cells and ECM\u003cbr\u003e\nInteraction: Endothelial cells, Epithelial cells, Leukocytes, Mesenchymal cells, Mesenchymal Stem Cells, B cells, Tregs\u003cbr\u003e\nLigand\/Receptor: Hyaluronan, MIP-1β, fibronectin, collagen\u003cbr\u003e\nCell Type: B cells, Dendritic cells, Mesenchymal Stem Cells, Tregs\u003cbr\u003e\nBiology Area: Cell Biology, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press. Haynes BF, et al. 1991. Cancer Cells. 3:347. Goldstein LA, et al. 1989. Cell. 56:1063. Mikecz K, et al. 1995. Nat. Med. 1:558. Hegde V, et al. 2008. J. Leukocyte Biol. 84:134. Liu T, et al. 2009. Biol Direct. 4:40.\u003cbr\u003e\nGene ID: 12505960\u003cbr\u003e\nUniProt: View information about CD44 on UniProt.org\u003cbr\u003e\nClone: C44Mab-5\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Hermes, Pgp-1, H-CAM, HUTCH-1, ECMR III, gp85, Ly-24\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862948630697,"sku":"397509","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-397509","provider":"Iright","version":"1.0","type":"link"}