{"product_id":"biolegend-397802","title":"Biolegend, 397802, Purified anti-human CD166 Antibody, 100μg","description":"\u003cp\u003eCD166, also known as the CD6 ligand or the Activated Leukocyte Cell Adhesion Molecule (ALCAM), is a 100-105 kD transmembrane glycoprotein. It belongs to the Ig superfamily of proteins and expressed on activated T cells, activated monocytes, epithelial cells, fibroblasts, and neurons. CD166 plays an important role in mediating adhesion interactions between thymic epithelial cells and CD6+ cells during intrathymic T cell development. Recently CD166 has also been used as a potential cancer stem cell marker. The antibody reacts with human activated leukocyte cell adhesion molecule (ALCAM).\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant human CD166\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: IHC-P - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5 - 10 µg\/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nProduct Citations: Ceccarelli S, et al. 2022. Front Cell Dev Biol. 10:926180. PubMed\u003cbr\u003e\nRRID: AB_2814379 (BioLegend Cat. No. 397802)\u003cbr\u003e\nStructure: A type I transmembrane glycoprotein belonging to the Ig superfamily of proteins.\u003cbr\u003e\nDistribution: CD166 is expressed on activated T cells, activated monocytes, epithelial cells, fibroblasts, and neurons.\u003cbr\u003e\nFunction: Play an important role in mediating adhesion interactions between thymic epithelial cells and CD6+ cells during intrathymic T cell development.\u003cbr\u003e\nLigand\/Receptor: CD6\u003cbr\u003e\nCell Type: B cells, Dendritic cells, Mesenchymal Stem Cells, Tregs\u003cbr\u003e\nBiology Area: Cell Biology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Aruffo A, et al. 1997. Immunol Today. 18(10):498. Patel DD, et al. 1995. J. Exp. Med. 181:2213. Bowen MA, et al. 1995. J. Exp. Med. 181:1563. Horst D, et al. 2009. Cancer Invest. 8:844-50.\u003cbr\u003e\nGene ID: 214\u003cbr\u003e\nUniProt: View information about CD166 on UniProt.org\u003cbr\u003e\nClone: A17193J\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CD6 ligand, Activated Leukocyte Cell Adhesion Molecule (ALCAM)\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866056315049,"sku":"397802","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-397802","provider":"Iright","version":"1.0","type":"link"}