{"product_id":"biolegend-399102","title":"Biolegend, 399102, Purified anti-human CD339 (Jagged 1) Antibody, 100μg","description":"\u003cp\u003eCD339, also known as Jagged 1, is a 135 kDa type 1 transmembrane protein with one DSL (Delta, Serrate, LagZ) domain, fifteen EGF-like domains, and one cysteine-rich region. Jagged 1 is expressed by many cell types including macrophages, subsets of dendritic cells, astrocytes, stromal, and epithelial cells. Jagged 1 regulates cell fate decisions in various tissues, and has an important role in neurogenesis and development of the cardiovascular system. Some studies suggest Jagged 1 is also involved in Th2 polarization and Treg induction.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Human Jagged-transfected RBL1 cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2832781 (BioLegend Cat. No. 399102)\u003cbr\u003e\nStructure: A 135 kD type 1 transmembrane protein with 1 DSL domain, 15 EGF-like domain and 1 cysteine-rich region.\u003cbr\u003e\nDistribution: Macrophages, subset of dendritic cells, astrocytes, stromal and epithelial cells.\u003cbr\u003e\nFunction: Regulate cell fate decisions in tissues, neurogenesis, Th2 polarization, and Treg induction\u003cbr\u003e\nLigand\/Receptor: Notch\u003cbr\u003e\nCell Type: Astrocytes, Dendritic cells, Epithelial cells, Macrophages, Monocytes\u003cbr\u003e\nBiology Area: Cardiovascular Biology, Immunology, Neuroscience\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Oda T, et al. 1997. Nat. Genet. 16:235. Li L, et al. 1997. Nat. Genet. 16:243. Guarnaccia C, et al. 2004. FEBS Letters. 574:156. High FA, et al. 2008. Proc. Natl. Acad. Sci. 105:1955. Kopan R and Ilagan MX. 2009. Cell. 137:216. Reedijk M, et al. 2005. Cancer Res. 65:8530. Grochowski CM, et al. 2016. Gene. 576:381. Hofmann JJ, et al. 2012. Development. 139:4449.\u003cbr\u003e\nGene ID: 182\u003cbr\u003e\nUniProt: View information about CD339 on UniProt.org\u003cbr\u003e\nClone: W16199B\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: JAG1, Jag-1, Jagged1, Jagged-1\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866308792489,"sku":"399102","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-399102","provider":"Iright","version":"1.0","type":"link"}