{"product_id":"biolegend-512301","title":"Biolegend, 512301, Purified anti-human IL-17A Antibody, 50μg","description":"\u003cp\u003eIL-17A is the founding member of the IL-17 family, a group of six structurally related pro-inflammatory cytokines. IL-17A, secreted by activated CD4 + Th17 cell subpopulation, elicits multiple biological activities on a variety of cells including: the induction of IL-6, IL-8, G-CSF, and PGE2 production in epithelial, endothelial or fibroblasts; the enhancement of surface expression of ICAM-1 in fibroblasts; activation of NF-κB and costimulation of T cell proliferation. Recent studies demonstrated that, in mice, activated IL-17-secreting CD4 + helper T cells (Th17 cells) mediate an autoimmune arthritis that clinically and immunologically resembles rheumatoid arthritis (RA). Human IL-17A shows 63%, 63%, and 72% amino acid sequence identity to rat IL-17A, mouse IL-17A, and a protein encoded by the ORF13 gene of herpesvirus Saimiri (HVS), respectively.\u003cbr\u003e\n50μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant full length human IL-17A\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: ICFC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µl volume or 100 µl of whole blood. It isrecommended that the reagent be titrated for optimalperformance for each application.\u003cbr\u003e\nProduct Citations: Alroqi F, et al. 2017. J Clin Immunol. . 10.1007\/s10875-017-0451-1. PubMed Willing A, et al. 2018. J Immunol. 200:974. PubMed Matthias J, et al. 2020. J Clin Invest. 130:4587. PubMed Kessel C, et al. 2017. Arthritis Rheumatol. 69:1480. PubMed Aravena O, et al. 2017. Arthritis Res Ther. 19:8. PubMed Ma F, et al. 2017. Exp Cell Res.. 10.1016\/j.yexcr.2017.10.011. PubMed Del Alcazar D, et al. 2019. Cell Rep. 28:3047. PubMed Sattler A, et al. 2021. Am J Transplant. 21:87. PubMed Lückel C, et al. 2019. Nat Commun. 4.390277778. PubMed Singh AK, et al. 2017. Front Immunol. 0.513888889. PubMed Mishra A, et al. 2021. Cell. 184(13):3394-3409.e20. PubMed Schwabenland M, et al. 2021. Immunity. . PubMed Umeda M, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed\u003cbr\u003e\nRRID: AB_961398 (BioLegend Cat. No. 512301) AB_961399 (BioLegend Cat. No. 512302)\u003cbr\u003e\nStructure: Cytokine; dimer; ~15 kD (Mammalian)\u003cbr\u003e\nBioactivity: Secretion of IL-6, IL-8, G-CSF, prostaglandin E2 by epithelial, endothelial or fibroblastic cells; stimulates cell migration, cord formation, and IL-6 secretion by stromal cells\u003cbr\u003e\nCell Sources: Activated T cell subpopulation\u003cbr\u003e\nCell Targets: Fibroblasts, epithelial and endothelial cells, stromal cells\u003cbr\u003e\nReceptors: IL-17R\u003cbr\u003e\nCell Type: Tregs\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Neuroinflammation, Neuroscience\u003cbr\u003e\nMolecular Family: Cytokines\/Chemokines\u003cbr\u003e\nAntigen References: 1. Hirota K, et al. 2007. J. Exp. Med. 204:41. 2. Furuzawa-Carballeda J, et al. 2007. Autoimmun. Rev. 6:169. 3. Witowski J, et al. 2007. Kidney Int. 71:514. 4. Gaffen SL, et al. 2006. Vitam. Horm. 74:255. 5. Hymowitz S, et al. 2001. EMBO J. 20:5332.\u003cbr\u003e\nGene ID: 3605\u003cbr\u003e\nUniProt: View information about IL-17A on UniProt.org\u003cbr\u003e\nClone: BL168\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Interleukin IL-17A, IL-17, Cytotoxic T lymphocyte-associated antigen 8 (CTLA-8)\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866084429993,"sku":"512301","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-512301","provider":"Iright","version":"1.0","type":"link"}