{"product_id":"biolegend-512333","title":"Biolegend, 512333, APC anti-human IL-17A Antibody, 25tests","description":"\u003cp\u003eIL-17A is the founding member of the IL-17 family, a group of six structurally related pro-inflammatory cytokines. IL-17A, secreted by activated CD4 + Th17 cell subpopulation, elicits multiple biological activities on a variety of cells including: the induction of IL-6, IL-8, G-CSF, and PGE2 production in epithelial, endothelial or fibroblasts; the enhancement of surface expression of ICAM-1 in fibroblasts; activation of NF-κB and costimulation of T cell proliferation. Recent studies demonstrated that, in mice, activated IL-17-secreting CD4 + helper T cells (Th17 cells) mediate an autoimmune arthritis that clinically and immunologically resembles rheumatoid arthritis (RA). Human IL-17A shows 63%, 63%, and 72% amino acid sequence identity to rat IL-17A, mouse IL-17A, and a protein encoded by the ORF13 gene of herpesvirus Saimiri (HVS), respectively.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant full length human IL-17A\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: ICFC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nProduct Citations: Rosenberg JM, et al. 2022. Med (N Y). 3:42. PubMed Wu X, et al. 2023. iScience. 26:106559. PubMed Shaw DG, et al. 2023. Nat Med. 29:1520. PubMed Nozawa K, et al. 2023. Front Immunol. 13:1084960. PubMed Lee YJ, et al. 2021. Front Immunol. 615369:12. PubMed Ogbechi J, et al. 2022. Front Immunol. 13:1001956. PubMed James E, et al. 2016. PLoS Pathog. 12: 1005375. PubMed Mutoh T, et al. 2020. Nat Commun. 11:1253. PubMed Su W, et al. 2022. Front Immunol. 13:952338. PubMed Zhan Y, et al. 2021. JCI Insight. 6:. PubMed Liang Y, et al. 2019. J Allergy Clin Immunol. 144:1025. PubMed Eken A, et al. 2020. North Clin Istanb. 0.513194444. PubMed Zhu Y, et al. 2019. Cell Stem Cell. 25:542. PubMed Martínez–Fábregas J, et al. 2019. Elife. 8:e49314. PubMed Martínez-Fábregas J, et al. 2020. Cell Rep. 33:108545. PubMed Maleki KT, et al. 2021. Cell Reports Medicine. 2(3):100220. PubMed Zhao Y, et al. 2020. Front Immunol. 2.572222222. PubMed Zhai Y, et al. 2018. Autophagy. 1.714583333. PubMed\u003cbr\u003e\nRRID: AB_2563985 (BioLegend Cat. No. 512333) AB_2563986 (BioLegend Cat. No. 512334)\u003cbr\u003e\nStructure: Cytokine; dimer; ~15 kD (Mammalian)\u003cbr\u003e\nBioactivity: Secretion of IL-6, IL-8, G-CSF, prostaglandin E2 by epithelial, endothelial or fibroblastic cells; stimulates cell migration, cord formation, and IL-6 secretion by stromal cells\u003cbr\u003e\nCell Sources: Activated T cell subpopulation\u003cbr\u003e\nCell Targets: Fibroblasts, epithelial and endothelial cells, stromal cells\u003cbr\u003e\nReceptors: IL-17R\u003cbr\u003e\nCell Type: Tregs\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Neuroinflammation, Neuroscience\u003cbr\u003e\nMolecular Family: Cytokines\/Chemokines\u003cbr\u003e\nAntigen References: 1. Hirota K, et al. 2007. J. Exp. Med. 204:41. 2. Furuzawa-Carballeda J, et al. 2007. Autoimmun. Rev. 6:169. 3. Witowski J, et al. 2007. Kidney Int. 71:514. 4. Gaffen SL, et al. 2006. Vitam. Horm. 74:255. 5. Hymowitz S, et al. 2001. EMBO J. 20:5332.\u003cbr\u003e\nGene ID: 3605\u003cbr\u003e\nUniProt: View information about IL-17A on UniProt.org\u003cbr\u003e\nClone: BL168\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Interleukin IL-17A, IL-17, Cytotoxic T lymphocyte-associated antigen 8 (CTLA-8)\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866081513641,"sku":"512333","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-512333","provider":"Iright","version":"1.0","type":"link"}