{"product_id":"biolegend-513002","title":"Biolegend, 513002, Purified anti-human IL-21 Antibody, 200μg","description":"\u003cp\u003eInterleukin 21 (IL-21) is a potent immunomodulatory cytokine primarily produced by NKT cells and CD4 + T cells, particularly the inflammatory Th17 subset. It exerts pleiotropic effects on both innate and adaptive immune responses. These include positive effects such as enhancing proliferation of NK cells and cytotoxic T cells, and inhibitory effects on the antigen-presenting function of dendritic cells. IL-21 also has proapoptotic effects on B cells and NK cells. Recent studies have shown that IL-21 functions as an autocrine cytokine, strongly inducing Th17 differentiation and suppressing Foxp3 expression, making it a potential therapeutic target for treating cancer and inflammatory diseases.\u003cbr\u003e\n200μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: Rhesus\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant full length human IL-21\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: ELISA Capture\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by ELISA assay. For ELISA capture applications, a concentration range of 2-6 µg\/ml is recommended. To obtain a linear standard curve, serial dilutions of IL-21 recombinant protein ranging from 2000 to 15 pg\/ml are recommended for each ELISA plate. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nProduct Citations: Drutman SB, et al. 2012. J Immunol. 3603:188. PubMed Meckiff BJ, et al. 2019. J Immunol. 203:1276. PubMed Tripathi T, et al. 2019. Immunohorizons. 0.201388889. PubMed Schwabenland M, et al. 2021. Immunity. . PubMed Bengsch B et al. 2018. Immunity. 48(5):1029-1045 . PubMed\u003cbr\u003e\nRRID: AB_1027620 (BioLegend Cat. No. 513001) AB_1027621 (BioLegend Cat. No. 513002)\u003cbr\u003e\nDistribution: Th17\u003cbr\u003e\nFunction: Immunomodulation\u003cbr\u003e\nCell Sources: NK-T cells and T cells\u003cbr\u003e\nCell Targets: Cytotoxic T cells (CTL) and Natural Killer (NK) cells that can destroy malignant or infected cells\u003cbr\u003e\nReceptors: IL-21R\u003cbr\u003e\nCell Type: Th17\u003cbr\u003e\nBiology Area: Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: Cytokines\/Chemokines\u003cbr\u003e\nAntigen References: 1. Nurieva R. 2007. Nature 448:416. 2. Parrish-Novak J, et al. 2002. J. Leukocyte Biol. 72:856. 3. Dumoutier L, et al. 2000. Proc. Natl. Acad. Sci. USA 97:10144. 4. Asao H, et al. 2001. J. Immunol. 167:1. 5. Parrish-Novak J, et al. 2000. Nature 408:57.\u003cbr\u003e\nGene ID: 59067\u003cbr\u003e\nUniProt: View information about IL-21 on UniProt.org\u003cbr\u003e\nClone: 3A3-N2\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Interleukin 21\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862385316009,"sku":"513002","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-513002","provider":"Iright","version":"1.0","type":"link"}