{"product_id":"biolegend-600302","title":"Biolegend, 600302, Purified anti-MRP-14 (S100A9) Antibody, 100μg","description":"\u003cp\u003eMRP-14, also known as S100A9, belongs to the S100 family of proteins containing 2-EF-hand calcium-binding motifs. It forms non-covalently associated complexes with another S100 family member, MRP-8. MRP14 is expressed in neutrophils and monocytes; it also has been found in ileal tissue eosinophils. The S100A8\/A9 complex has been shown to play a role during calcium-dependent activation as well as have antibacterial, antifungal, immunomodulating, and anti-proliferative effects. It also functions as a chemoattractant factor for neutrophils and has been considered an endogenous activator of Toll-like receptor 4. S100A9 has been identified as a marker for CD14(+) HLA-DR(-\/low) MDSCs.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant human S100A8\/S100A9 protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.05 - 0.5 µg per mL (1:1000-1:10000). It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: This clone does not recognize S100A8. The 114 amino acid recombinant S100A9 protein has a predicted Mw of ~13 kD for monomer and ~26 kD for dimer.\u003cbr\u003e\nProduct Citations: Roussel M, et al. 2021. Cell Reports Medicine. 2(6):100291. PubMed\u003cbr\u003e\nRRID: AB_2721746 (BioLegend Cat. No. 600301) AB_2721747 (BioLegend Cat. No. 600302)\u003cbr\u003e\nStructure: Belongs to S100 family of proteins containing 2-EF-hand calcium -binding motifs, forms non-covalently associated complexes with another S100 family member MRP-8. S100A9 has 114 amino acids with the predicted Mw of ~13 kDa.\u003cbr\u003e\nDistribution: MDSCs, neutrophils, monocyte, and ileal tissue eosinophils\u003cbr\u003e\nFunction: Calcium-dependent activation, immunomodulating and antiproliferative, endogenous activator of Toll-like receptor 4\u003cbr\u003e\nInteraction: Calcium, S100A8\u003cbr\u003e\nLigand\/Receptor: RAGE, TLR4\u003cbr\u003e\nCell Type: Neutrophils, Monocytes, Eosinophils\u003cbr\u003e\nBiology Area: Cancer Biomarkers, Cell Biology, Immunology, Innate Immunity\u003cbr\u003e\nAntigen References: 1. Loser K, et al. 2010. Nat. Med. 16:713. 2. Cheng P, et al. 2008. J. Exp. Med. 205:2235. 3. Leukert N, et al. 2006. J. Mol. Biol. 359:961-72. 4. Lagasse E, et al. 1988. Mol. Cell. Biol. 8:2402. 5. Zhao F, et al. 2012. Immunology. 136:176.\u003cbr\u003e\nGene ID: 6280\u003cbr\u003e\nUniProt: View information about MRP-14 on UniProt.org\u003cbr\u003e\nClone: A15105J\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: S100A9, Migration inhibitory factor-related proteins-14, Calgranulin-B, Leukocyte L1 complex heavy chain, Calprotectin L1H subunit\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864386162857,"sku":"600302","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-600302","provider":"Iright","version":"1.0","type":"link"}