{"product_id":"biolegend-602851","title":"Biolegend, 602851, Purified anti-NOS1 Antibody, 25μg","description":"\u003cp\u003eNitric oxide synthase 1 (NOS1) catalyzes the formation of nitric oxide (NO) from L-arginine. NO signals in neurons intracellularly to regulate metabolic activity and dendrite growth. NO also functions in neurons as a neurotransmitter-like signaling molecule, and in muscle cells, where it is a potent relaxer. High concentrations of NO are cytotoxic, so it is utilized by macrophages as a bactericide\/tumoricide, and it has also been implicated in the progression of neurodegenerative disorders like Alzheimer’s.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant fragment of human NOS1 protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested IHC-P - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.5 - 1.0 µg\/mL. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration of 5 - 10 µg\/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: This product was tested and failed for IHC-F in mouse brain.\u003cbr\u003e\nRRID: AB_2910479 (BioLegend Cat. No. 602851) AB_2910479 (BioLegend Cat. No. 602852)\u003cbr\u003e\nStructure: NOS1 is a 1,434 amino acid protein with a predicted molecular weight of 161 kD.\u003cbr\u003e\nDistribution: NOS1 is expressed in the cytoplasm of neurons, skeletal and smooth muscle cells, and macrophages.\u003cbr\u003e\nFunction: NOS1 is an enzyme that synthesizes nitric oxide.\u003cbr\u003e\nCell Type: Macrophages, Mature Neurons, Neurons\u003cbr\u003e\nAntigen References: Kourosh-Arami M, et al. 2019. Rev. Neurosci. 31:617-636. Jin R and Loscalzo J. 2010. J. Blood Med. 1:147-162.\u003cbr\u003e\nGene ID: 4842\u003cbr\u003e\nUniProt: View information about NOS1 on UniProt.org\u003cbr\u003e\nClone: W19138A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Nitric oxide synthase (NOS1), neuronal NOS (N-NOS)\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866345853097,"sku":"602851","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-602851","provider":"Iright","version":"1.0","type":"link"}