{"product_id":"biolegend-604752","title":"Biolegend, 604752, Purified anti-ATP1A1 Antibody, 100μg","description":"\u003cp\u003eATP1A1 is part of the P-type cation transport ATPases. It is the α 1 subunit of Na+\/K+ ATPase which catalyzes the hydrolysis of ATP and the exchange of Na+ and K+ maintaining their balance across the plasma membrane. In addition to regulating membrane homeostasis, the α subunit (ATP1A1) particularly plays a role in mediating viral infection, e.g., coronavirus and respiratory syncytial virus. Mutations in this gene has been associated with Charcot-Marie-Tooth disease type 2DD (CMT2DD), and Hypomagnesemia, Seizures, and Mental Retardation 2 (HOMGSMR2).\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Synthetic peptide conjugated to KLH\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested IHC-P, ICC - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.125 - 0.5 µg\/mL. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 1.0 - 10.0 µg\/mL is suggested. For immunocytochemistry, a concentration range of 2.5 - 5.0 μg\/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: For ICC, we recommend 4% PFA fixation followed by permeabilization with ice cold methanol, or fixation\/permeabilization with ice cold methanol alone. We do not recommend 4% PFA fixation followed by permeabilization with 0.5% Triton-X.\u003cbr\u003e\nRRID: AB_2924609 (BioLegend Cat. No. 604751) AB_2924609 (BioLegend Cat. No. 604752)\u003cbr\u003e\nStructure: ATP1A1 can be processed by alternative splicing into 4 different isoforms; isoform 1 is a 1023 aa protein with a predicted molecular weight of 113kD.\u003cbr\u003e\nDistribution: ATP1A1 is widely expressed in the plasma membrane of most tissues.\u003cbr\u003e\nFunction: ATP1A1 is an ATPase involved in maintaining the balance of Na+ and K+ across of the plasma membrane.\u003cbr\u003e\nBiology Area: Cell Biology, COVID-19\u003cbr\u003e\nMolecular Family: Enzymes and Regulators, Ion Channels\u003cbr\u003e\nAntigen References: Takase S, et al. 2017. Sci Rep. 7:2002. Wu IC, et al. Oncotarget. 2016 Dec 20;7(51):85244-85258 Schlingmann KP, et al. 2018. Am J Hum Genet. 103:808-816. Zacherl S, et al. 2015. J Biol Chem. 290:3654-65. Azizan EA, et al. 2013. Nat Genet. 45:1055-60.\u003cbr\u003e\nGene ID: 476\u003cbr\u003e\nUniProt: View information about ATP1A1 on UniProt.org\u003cbr\u003e\nClone: A19182B\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Sodium\/potassium-transporting ATPase subunit alpha-1 (ATP1A1), Na(+)\/K(+) ATPase alpha-1 subunit, Sodium pump subunit alpha-1, ATPase Na+\/K+ transporting subunit alpha 1\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866067259561,"sku":"604752","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-604752","provider":"Iright","version":"1.0","type":"link"}