{"product_id":"biolegend-611151","title":"Biolegend, 611151, Purified anti-Peroxiredoxin 1 Antibody, 25μg","description":"\u003cp\u003ePeroxiredoxin 1, also called PRDX1, is one of six members of the superfamily of thiol-dependent peroxidases. Peroxiredoxin 1 can eliminate reactive oxygen and nitrogen species. As a critical antioxidant enzyme, it utilizes an N-terminal cystine to detoxify peroxides and protect cells from oxidative stress damage. As a sensor of inflammation response, extracellular Peroxiredoxin 1 is released to trigger TLR4-dependent secretion of TNF-α and IL-6 in macrophage and dendritic cell maturation. Peroxiredoxin 1 is increased in bone marrow-derived macrophages by lipopolysaccharide (LPS) and IFN-γ exposure. In microglia, the expression level of Peroxiredoxin 1 is regulated through ROS\/p38\/MAPK pathway and protects microglia from cell death. Overexpression of Peroxiredoxin 1 in rat primary hippocampus neuronal and PC12 cells promotes survival under amyloid β toxicity. In addition to its role as an antioxidant, oxidized Peroxiredoxin 1 forms an oligomer that acts as a chaperone to suppress the c-Myc oncogene and promotes tumor cell apoptosis.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse, Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant protein of human Peroxiredoxin 1\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested ICC - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.1 - 1.0 µg\/mL. For immunocytochemistry, a concentration of 5.0 μg\/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: This product is not recommended for use in IHC-P. For immunocytochemistry, fixation with ice-cold methanol is recommended.\u003cbr\u003e\nRRID: AB_2936735 (BioLegend Cat. No. 611151) AB_2936735 (BioLegend Cat. No. 611152)\u003cbr\u003e\nStructure: Peroxiredoxin 1 is a 199 amino acid protein with an expected molecular weight of 22 kD. It exists as a homodimer and homodecamer.\u003cbr\u003e\nDistribution: Mainly expressed in cytoplasm; Distributed ubiquitously across tissues\u003cbr\u003e\nFunction: Catalyzes the reduction of hydrogen peroxide and organic hydroperoxides\u003cbr\u003e\nInteraction: Peroxiredoxin 1, PTEN, Androgen receptor, C-ABL\u003cbr\u003e\nBiology Area: Apoptosis\/Tumor Suppressors\/Cell Death, Cell Biology, Cell Death, Signal Transduction, Transcription Factors\u003cbr\u003e\nAntigen References: Shau H, et al. 1993. Cell Immunol. 147:1-11. Wood ZA, et al. 2003. Trends Biochem. Sci. 28:32-40. Cumming RC, et al. 2007. J Biol Chem. 282:30523-34. Kim SU, et al. 2008. Biol Pharm Bull. 31:820-5.\u003cbr\u003e\nGene ID: 5052\u003cbr\u003e\nUniProt: View information about Peroxiredoxin 1 on UniProt.org\u003cbr\u003e\nClone: 6A6-4H3-7A3\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: PRDX1, Natural killer cell-enhancing factor A, NKEF-A, Proliferation-associated gene protein, PAG, Thioredoxin peroxidase 2, Thioredoxin-dependent peroxide reductase 2, Thioredoxin-dependent peroxiredoxin 1, PAGA, PAGB, TDPX2\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862471889065,"sku":"611151","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-611151","provider":"Iright","version":"1.0","type":"link"}