{"product_id":"biolegend-611551","title":"Biolegend, 611551, Purified anti-human ALK Antibody, 25μg","description":"\u003cp\u003eALK is expressed widely in the central nervous system, where it plays important roles in neurogenesis and the development of the nervous system. ALK is a receptor tyrosine kinase that phosphorylates tyrosines on target proteins upon ligand binding (known ligands include pleiotrophin, midkine, FAM150A, and FAM150B). ALK was originally discovered in anaplastic large-cell lymphoma cells where a chromosomal translocation leads to constitutive activation of the ALK kinase domain, making ALK a target of inhibition in cancer therapies.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant fragment of human ALK\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.5 - 1.0 µg\/mL. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: W16189A is not suitable for ICC, FC, and IHC-P. W16189A is weakly cross-reactive with mouse ALK in WB.\u003cbr\u003e\nRRID: AB_2941602 (BioLegend Cat. No. 611551) AB_2941602 (BioLegend Cat. No. 611552)\u003cbr\u003e\nStructure: ALK is a 1,620 amino acid protein with a predicted molecular weight of 176.4 kD.\u003cbr\u003e\nDistribution: ALK is expressed in the plasma membrane and is expressed in many neuronal subtypes in specific regions of the central and peripheral nervous system.\u003cbr\u003e\nFunction: Upon ligand binding ALK dimerizes and autophosphorylates, gaining kinase activity\u003cbr\u003e\nInteraction: ALK phosphorylates members of the MAPK and NF-KB signaling pathways\u003cbr\u003e\nLigand\/Receptor: ALK activation can proceed via binding of pleiotrophin, midkine, FAM150A or FAM150B\u003cbr\u003e\nCell Type: Neurons\u003cbr\u003e\nBiology Area: Cell Proliferation and Viability\u003cbr\u003e\nMolecular Family: CD Molecules, Protein Kinases\/Phosphatase\u003cbr\u003e\nAntigen References: Souttou B, et al. 2001. J Biol Chem. 276:9526-31. Hallberg B, et al. 2016. Ann Oncol. 27 Suppl 3:iii4-iii15.\u003cbr\u003e\nGene ID: 238\u003cbr\u003e\nUniProt: View information about ALK on UniProt.org\u003cbr\u003e\nClone: W16190A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Anaplastic lymphoma kinase (ALK), ALK tyrosine kinase receptor, cluster of differentiation 246 (CD246), Mutant Anaplastic Lymphoma Kinase, NBLST3\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866306662569,"sku":"611551","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-611551","provider":"Iright","version":"1.0","type":"link"}