{"product_id":"biolegend-616152","title":"Biolegend, 616152, Purified anti-CD340 (ErbB2\/HER-2) Antibody, 100μg","description":"\u003cp\u003eCD340 is the protein HER2, a member of the epidermal growth factor receptor (EGFR) family of cell membrane tyrosine kinases, and is encoded by the gene ErbB2. Unlike other EGFR family members, CD340 contains no ligand binding domain and has no known ligands. Instead, this protein interacts with other EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated downstream signaling. CD340 has been shown to be involved in embryonic development and cancer progression; this protein is amplified in adenocarcinoma of the lung, some breast cancers, glioblastoma, gastric cancer, and ovarian carcinoma, where it functions as an oncogene. Overexpression of ErbB2 in breast cancers has been shown to confer Taxol resistance and is a therapeutic target in a number of human cancers.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant fragment of human ErbB2, N-terminus\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: ICC - Quality tested FC - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunocytochemistry. For immunocytochemistry, a concentration range of 1.25 - 5.0 μg\/mL is recommended. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: This product is not recommended for use in IHC-P.\u003cbr\u003e\nRRID: AB_3068205 (BioLegend Cat. No. 616151) AB_3068205 (BioLegend Cat. No. 616152)\u003cbr\u003e\nStructure: CD340 is a 1,255 amino acid protein with a predicted molecular weight of 137.9 kD.\u003cbr\u003e\nDistribution: Expressed on the cell surface of many tumor cells including some breast cancers, lung adenocarcinoma, gastric cancer, ovarian cancer, glioblastoma, some c-ALL blasts and bone marrow MSCs\u003cbr\u003e\nFunction: Contains no ligand binding domain and interacts with other EGF receptor family members to form a heterodimer, stabilize ligand binding, and enhance kinase-mediated downstream signaling. Involved in embryonic development and cancer progression.\u003cbr\u003e\nInteraction: CD340 interacts with a large number of proteins, including SHC1, EGF receptor, neuregulin 1, c-Src, integrin β4, Grb2, Grb7, SOS1, caveolin-1, JAK2, PAK1, FAK, and β-catenin, among others.\u003cbr\u003e\nLigand\/Receptor: Despite being a member of the epidermal growth factor receptor (EGFR) family, no ligand of CD340 has been identified.\u003cbr\u003e\nCell Type: Leukemia\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Neuroscience, Synaptic Biology\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: Akiyama T, et al. 1986. Science. 232:1644-6. Bargmann CI, et al. 1986. Nature. 319:226-30. Pegram MD, et al. 1997. Oncogene. 15:537-47. Slamon DJ, et al. 1989. Science. 244:707-12. Leone F, et al. 2003. J Leukocyte Biol. 74:593-601.\u003cbr\u003e\nGene ID: 2064\u003cbr\u003e\nUniProt: View information about CD340 on UniProt.org\u003cbr\u003e\nClone: A20145B\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: HER2\/erbB2, tyrosine kinase cell surface receptor HER2, oncogene ERBB2, oncogene NGL, neuroblastoma- or glioblastoma-derived, HER-2\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866071617705,"sku":"616152","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-616152","provider":"Iright","version":"1.0","type":"link"}