{"product_id":"biolegend-618401","title":"Biolegend, 618401, Purified anti-SENP2 Antibody, 25μg","description":"\u003cp\u003eIn eukaryotes, sumoylation (SUMO) is a post-translational modification that contributes to the degradation of proteins harboring the modification. Sentrin-specific protease 2 (SENP2) is an enzyme that is critical for maintaining SUMO homeostasis. There are six described SENP isoforms; each share a highly- conserved catalytic domain in the C-terminus region. SENP2 is localized to the nucleus and catalyzes the deconjugation of SUMO1\/2\/3 moieties from target proteins. SENP2 has been shown to regulate the level of p53 by desumoylating Mdm2.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Synthetic human SENP2 peptide corresponding to amino acids 562-578\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 1.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: We do not recommended this clone for IP or ICC applications.\u003cbr\u003e\nRRID: AB_2810677 (BioLegend Cat. No. 618401) AB_2810678 (BioLegend Cat. No. 618402)\u003cbr\u003e\nStructure: SENP2 is a 589 amino acid protein with a predicted molecular weight of 67.9 kD.\u003cbr\u003e\nDistribution: Nucleus and nuclear pore complex\/ubiquitously expressed\u003cbr\u003e\nFunction: Protein turnover\u003cbr\u003e\nBiology Area: Cell Biology\u003cbr\u003e\nMolecular Family: Protein Modifiers\u003cbr\u003e\nAntigen References: Hang J and Dasso M. 2002. J.Biol. Chem. 277:19961 Chiu SY, et al. 2008. PLoS Biol. 6:e310 Nayak A and Müller S. 2014. Genome Biol.15:422\u003cbr\u003e\nGene ID: 59343\u003cbr\u003e\nUniProt: View information about SENP2 on UniProt.org\u003cbr\u003e\nClone: W17126B\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: SUMO Specific Peptidase 2, SUMO1\/Sentrin\/SMT3 Specific Peptidase 2, SUMO1\/Sentrin\/SMT3 Specific Protease 2, Sentrin\/SUMO-Specific Protease SENP2, Sentrin (SUMO1) Specific Peptidase 2, SMT3-Specific Isopeptidase 2, Sentrin-Specific Protease 2\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866313314473,"sku":"618401","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-618401","provider":"Iright","version":"1.0","type":"link"}