{"product_id":"biolegend-625602","title":"Biolegend, 625602, Purified anti-PLZF Antibody, 100μg","description":"\u003cp\u003ePromyelocytic leukaemia zinc finger protein (PLZF) is a transcription factor that belongs to the POK (POZ and Krüppel) family of transcriptional repressors. It is involved in cell cycle control, and plays an essential role in limb development, differentiation of myeloid cells, and spermatogenesis. In certain acute myeloid leukemias, PLZF exists as a translocation product with Retinoic Acid Receptor-α (PLZF-RARα) that has a dominant negative effect on hematopoietic differentiation and is capable of activating Wnt signaling by upregulating the γ-catenin promoter. PLZF can also repress transcription of TP53 and also destabilizes p53 protein through enhanced ubiquitination.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Partial recombinant human PLZF protein corresponding to amino acid residues 1-254\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 1.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: This clone has not been tested for ICC or IP.\u003cbr\u003e\nRRID: AB_2814490 (BioLegend Cat. No. 625601) AB_2814491 (BioLegend Cat. No. 625602)\u003cbr\u003e\nStructure: PLZF is a 673 amino acid protein with a predicted molecular weight of 74 kD.\u003cbr\u003e\nDistribution: Nucleus\/widely expressed\u003cbr\u003e\nFunction: Transcriptional repressor\/epigenetic regulator\u003cbr\u003e\nCell Type: Mesenchymal Stem Cells, NKT cells, T cells\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Signal Transduction, Stem Cells, Transcription Factors\u003cbr\u003e\nAntigen References: Choi WI, et al. 2014. J. Biol. Chem. 289: 18625. Constantinides MG, et al. 2011. J. Immunol. 187:309. Kovalovsky D, et al. 2008. Nat. Immunol. 9:1055. Zheng X, et al. 2004. Blood. 103:3535. Chen Z, et al. 1994. Proc. Natl. Acad. Sci. USA 91:1178. Chen Z, et al. 1993. EMBO J. 12:1161.\u003cbr\u003e\nGene ID: 7704\u003cbr\u003e\nUniProt: View information about PLZF on UniProt.org\u003cbr\u003e\nClone: W18031A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: ZBTB16, Zinc Finger And BTB Domain Containing 16, ZNF145, Promyelocytic Leukaemia Zinc Finger\u003cbr\u003e\nIsotype: Rat IgG2b, λ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866329862313,"sku":"625602","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-625602","provider":"Iright","version":"1.0","type":"link"}