{"product_id":"biolegend-627001","title":"Biolegend, 627001, Purified anti-GRB2 Antibody, 25μg","description":"\u003cp\u003eGRB2 is a receptor tyrosine kinase (RTK) adaptor protein that transduces signaling cascades from activated receptors. Upon receptor stimulation, GRB2 binds phosphorylated RTK tyrosine residues via a central SH2 domain; flanking GRB2 SH3 domains facilitate the recruitment of downstream effectors to the activated RTK.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Synthetic peptide corresponding to amino acid residues 199-214 of human GRB2.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 1.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: This clone has not been tested for ICC or IP.\u003cbr\u003e\nRRID: AB_2810687 (BioLegend Cat. No. 627001) AB_2810688 (BioLegend Cat. No. 627002)\u003cbr\u003e\nStructure: GRB2 is a 217 amino acid protein with a predicted molecular weight of 25 kD.\u003cbr\u003e\nDistribution: Plasma membrane-associated\/ubiquitously expressed\u003cbr\u003e\nFunction: Adaptor protein in RTK signaling pathways\u003cbr\u003e\nBiology Area: Cell Biology, Signal Transduction\u003cbr\u003e\nMolecular Family: Adaptor Proteins, Phospho-Proteins\u003cbr\u003e\nAntigen References: Lowenstein EJ, et al. 1992. Cell. 70:431-42. Matuoka K, et al. 1992. Proc Natl Acad Sci U S A. 89:9015-9. Skolnik EY, et al. 1993. Science. 260:1953-5. Pendergast AM, et al. 1993. Cell. 75:175-85.\u003cbr\u003e\nGene ID: 2885\u003cbr\u003e\nUniProt: View information about GRB2 on UniProt.org\u003cbr\u003e\nClone: W17230A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Growth Factor Receptor Bound Protein 2, SH2\/SH3 Adaptor Protein GRB2, ASH, Epidermal Growth Factor Receptor-Binding Protein GRB2, Abundant SRC Homology, MSTP084, Grb3-3, MST084, NCKAP2\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866315739305,"sku":"627001","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-627001","provider":"Iright","version":"1.0","type":"link"}