{"product_id":"biolegend-633901","title":"Biolegend, 633901, Purified anti-Bcl-X, 25μg","description":"\u003cp\u003eBcl-X belongs to Bcl-2 family, and has several alternative splicing isoforms. It plays a critical role in control of apoptosis. The large isoform Bcl-XL (26kD) contains the highly conserved BH1\/BH2 domain and protects cells from apoptosis, whereas the short isoform, Bcl-XS (19kD), which lacks of conserved BH1\/BH2 domain, promotes apoptosis by interacting with Bcl-XL and Bcl-2. Bcl-XS is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-XL is found in long-lived, post-mitotic cells, such as adult brain.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Bcl-XS\/L (3-14 amino acid, conserved in both human and mouse)\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: Upon receipt, store undiluted at between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested IP - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Hsu YT, et al. 1997. J. Biol. Chem. 272:13829.\u003cbr\u003e\nProduct Citations: Kim HY, et al. 2014. Nat Med. 54:20. PubMed Hollenbaugh JA, et al. 2016. Virology. 106:491. PubMed Wang F, et al. 2020. Int J Oncol. 57:707. PubMed Inao T, et al. 2018. Oncotarget. 144:318. PubMed\u003cbr\u003e\nRRID: AB_2064708 (BioLegend Cat. No. 633901) AB_2064706 (BioLegend Cat. No. 633902)\u003cbr\u003e\nStructure: Five alternative splicing isoforms: Bcl-XS, Bcl-XL, Bcl-Xβ, Bcl-X, Bcl-XδTM\u003cbr\u003e\nDistribution: Bcl-XS is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-XL is found in long-lived, post-mitotic cells, such as adult brain.\u003cbr\u003e\nFunction: Bcl-X plays a critical role in the control of apoptosis. The large isoform Bcl-XL (26kD) contains the highly conserved BH1\/BH2 domain and protects cells from apoptosis, whereas the short isoform, Bcl-XS (19kD), which lacks of conserved BH1\/BH2 domain, promotes apoptosis by interacting with Bcl-XL and Bcl-2.\u003cbr\u003e\nInteraction: Bcl-2, Cytochrome C, JNK1, BAG 1, Caspase 8, Caspase 9, c-FLIP, Bax, p53\u003cbr\u003e\nBiology Area: Apoptosis\/Tumor Suppressors\/Cell Death, Cell Biology, Neuroscience\u003cbr\u003e\nAntigen References: 1. Boise LH, et al. 1993 Cell 74:597\u003cbr\u003e\nGene ID: 598\u003cbr\u003e\nUniProt: View information about Bcl-XS\/L on UniProt.org\u003cbr\u003e\nClone: 2H12\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Apoptosis regulator Bcl-X, Bcl-2-like 1 protein\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862327611561,"sku":"633901","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-633901","provider":"Iright","version":"1.0","type":"link"}