{"product_id":"biolegend-648001","title":"Biolegend, 648001, Purified anti-Hsp70 Antibody, 25μg","description":"\u003cp\u003eHsp70 is a member of the Hsp family of highly conserved proteins that play a role in a number of important functions. Their synthesis is increased upon environmental stress. They function by acting as molecular chaperones, facilitating protein refolding and preventing protein aggregation. It has been reported that extracellular Hsp70 also exhibits immunomodulatory effects on innate and acquired immunity.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Hsp70 protein from HeLa cells.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB, ICFC - Quality tested ICC - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.25 - 1.0 µg per ml. For immunocytochemistry, the suggested use of this reagent is 1.0 - 5.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nProduct Citations: Fong J, et al. 2015. EMBO J. 34: 2775 - 2788. PubMed Zhang K, et al. 2021. Neuron. 109(12):1949-1962.e6. PubMed Våtsveen TK, et al. 2018. J Hematol Oncol. 11:23. PubMed Harris IS et al. 2019. Cell metabolism. 29(5):1166-1181 . PubMed Hashimoto M, et al. 2022. Front Neurosci. 16:948517. PubMed\u003cbr\u003e\nRRID: AB_2028531 (BioLegend Cat. No. 648001) AB_2264228 (BioLegend Cat. No. 648002)\u003cbr\u003e\nStructure: Hsp proteins are the most conserved proteins present in both prokaryotes and eukaryotes. Human HSp70 contains multiple isoforms. Hsp70s consisit of three structural domains, a 44Kd amino-terminal ATPase domain (NBD), followed by an 18 Kd substrate\u003cbr\u003e\nDistribution: Ubiquitous, cytoplasmic and nuclear\u003cbr\u003e\nFunction: Molecular chaperrones assisting in the folding of proteins and preventing protein aggregation\u003cbr\u003e\nBiology Area: Cell Biology, Neurodegeneration, Neuroinflammation, Neuroscience, Protein Trafficking and Clearance\u003cbr\u003e\nAntigen References: 1. Sharma D, et al. 2009. Protein Peptide Lett. 16:571. 2. Johnson JD, et al. 2006. J. Leuk. Biol. 79:425. 3. Bukau B, et al. 1998. Cell 92:351.\u003cbr\u003e\nGene ID: 3308\u003cbr\u003e\nUniProt: View information about Hsp70 on UniProt.org\u003cbr\u003e\nClone: W27\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Heat shock protein 70\u003cbr\u003e\nIsotype: Mouse IgG2a, λ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864085057705,"sku":"648001","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-648001","provider":"Iright","version":"1.0","type":"link"}