{"product_id":"biolegend-651751","title":"Biolegend, 651751, Purified anti-SHP-2 Phospho (Tyr542) Antibody, 25μg","description":"\u003cp\u003eSHP-2 is encoded by the PTPN11 gene, is a well-known oncogenic member of the protein tyrosine phosphatase (PTP) family. SHP-2 regulates cellular functions by dephosphorylating targets downstream of PD1, EGFRvIII, HGF receptor, and cytokine receptors. Cellular processes controlled by SHP-2 include mitotic cycle, cell growth, differentiation, and oncogenesis. Phosphorylation of tyrosine 542 and 580 of SHP-2 in response to growth factor receptor activation leads to a stimulation in its tyrosine phosphatase activity. SHP-2 has been recognized as a potential therapeutic target for cancers including breast cancer, lung cancer, leukemia, gastric cancer, and oral cancer.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Synthetic peptide of human SHP-2 phosphorylated at Tyr542\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.25 - 1.0 µg\/mL. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_3683489 (BioLegend Cat. No. 651751) AB_3683489 (BioLegend Cat. No. 651752)\u003cbr\u003e\nStructure: SHP-2 is a 593 amino acid protein with a molecular mass of 68 kD.\u003cbr\u003e\nDistribution: Cytoplasm, Nucleus\u003cbr\u003e\nFunction: SHP-2 regulates cell proliferation, apoptosis, invasion, and metastasis\u003cbr\u003e\nInteraction: SHP-2 interacts with PD1, EGFR, HGF receptor, RET, FGFR2, FGFR3, PI3K\/AKT, and TLR3 signaling pathways.\u003cbr\u003e\nBiology Area: Adaptive Immunity, Cell Biology, Immuno-Oncology, Immunology, Signal Transduction\u003cbr\u003e\nMolecular Family: Protein Kinases\/Phosphatase\u003cbr\u003e\nAntigen References: Hao C, et al. 2020. Oncogene. 39:7166-7180. Marie D, et al. 2008. Cell Signal. 20:453-9. Cheng Kui QU. 2000. Cell Research. 10:279-288. Bennett AM, et al. 1994. Proc Natl Acad Sci USA. 91:7335.\u003cbr\u003e\nGene ID: 5781\u003cbr\u003e\nUniProt: View information about SHP-2 Phospho Tyr542 on UniProt.org\u003cbr\u003e\nClone: A22019A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: PTPN11, CFC, NS1, JMML, SHP2, BPTP3, PTP2C, METCDS, PTP-1D, SH-PTP2, SH-PTP3, Syp, Protein Tyrosine Phosphatase Non-Receptor Type 11, SH2 Domain-Containing Protein Tyrosine Phosphatase 2\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866076303529,"sku":"651751","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-651751","provider":"Iright","version":"1.0","type":"link"}