{"product_id":"biolegend-652301","title":"Biolegend, 652301, Purified anti-human CD304 Antibody, 25μg","description":"\u003cp\u003eThe membrane isoform of CD304 is a receptor that regulates angiogenesis and organogenesis in response to growth factors of the VEGF family. CD304 forms a complex with VEGFR2\/KDR, resulting in increased cell migration and chemotaxis. In the nervous system, CD304 complexed with plexin mediates Sema-3A signaling and may be involved in axon guidance.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: 293E expressed human CD304 recombinant protein, b isoform\u003cbr\u003e\nFormulation: This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.Previous lots of this product may have been formulated with 0.1% or 0.05% NaN3 instead of 0.09% NaN3. For further information please contact BioLegend Technical Support or Customer Service.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: Upon receipt, store undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 µl per 5 ml antibody dilution buffer for each mini-gel (1 µg\/ml). It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_11203372 (BioLegend Cat. No. 652302)\u003cbr\u003e\nStructure: Single-pass type I membrane protein, 103 kD. Contains two CUB motifs, domains similar to coagulation factors V and VIII, and a MAM domain in the extracellular domain. Isoform b is a soluble form.\u003cbr\u003e\nDistribution: Membrane, Secreted (isoform b).\u003cbr\u003e\nFunction: CD304 is a VEGF co-receptor involved in axon guidance, angiogenesis. and development of cardiovascular system. The secreted isoform inhibits binding of VEGF-165 to cells.\u003cbr\u003e\nLigand\/Receptor: CD304 is a receptor for members of VEGF family and pro-angiogenesis cytokines, such as VEGF-A165, VEGF-B, VEGF-E, and PIGF-2.\u003cbr\u003e\nBiology Area: Angiogenesis, Cell Biology, Immunology, Signal Transduction\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Soker S, et al. 1998. Cell 92:735. 2. Shintani Y, et al. 2006. EMBO J. 25:3045. 3. He Z, et al. 1997. Cell 90:739. 4. Gagnon ML, et al. 2000. P. Natl. Acad. Sci. USA 97:2573. 5. Glinka Y, et al. 2011. Carcinogenesis 32:613.\u003cbr\u003e\nGene ID: 8829\u003cbr\u003e\nUniProt: View information about CD304 on UniProt.org\u003cbr\u003e\nClone: 14H4\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Neuropilin 1\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864350183593,"sku":"652301","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-652301","provider":"Iright","version":"1.0","type":"link"}