{"product_id":"biolegend-654652","title":"Biolegend, 654652, Purified anti-DNER Antibody, 100μg","description":"\u003cp\u003eDNER is a type I transmembrane protein primarily expressed in the nervous system. First identified as a non-canonical Notch ligand, DNER plays a crucial role in neuronal differentiation. DNER is particularly involved in neuron-glial interactions, and abnormalities in DNER function have been associated with neurological disorders and impaired brain development. DNER is expressed in many tissue types and plays a role in a variety of diseases such as COPD, periodontitis, and breast cancer.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant protein corresponding to the N terminus of human DNER\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: IHC-P - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 1.0 - 10.0 µg\/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nAdditional Product Notes: For use in immunohistochemistry on formalin-fixed paraffin-embedded tissue (IHC-P), it is recommended to perform antigen retrieval using either Citrate Buffer, 10X (Cat. No. 420902) or Tris-EDTA pH 9.0 Antigen Retrieval Buffer (10X) (Cat. No. 422704). This product is not recommended for use in Western blot (WB), flow cytometry (FC), intracellular flow cytometry (ICFC) or immunocytochemistry (ICC).\u003cbr\u003e\nRRID: AB_3699080 (BioLegend Cat. No. 654651) AB_3699080 (BioLegend Cat. No. 654652)\u003cbr\u003e\nStructure: DNER is a 737 amino acid protein with an expected molecular weight of 78.5 kD.\u003cbr\u003e\nDistribution: Cell membrane\u003cbr\u003e\nFunction: Notch activator\u003cbr\u003e\nInteraction: α- and β- spectrin, GFAP\u003cbr\u003e\nLigand\/Receptor: Notch 1, Notch 2\u003cbr\u003e\nCell Type: Neurons\u003cbr\u003e\nBiology Area: Cell Biology, Neuroscience, Neuroscience Cell Markers, Signal Transduction\u003cbr\u003e\nAntigen References: Eiraku M, et al. 2005. Nat Neurosci. 8:873-80. Saito SY and Takeshima H 2006. Cerebellum. 5:227-31. Hiseh FY, et al. 2013. Dev Biol. 375:1-12.\u003cbr\u003e\nGene ID: 92737\u003cbr\u003e\nUniProt: View information about DNER on UniProt.org\u003cbr\u003e\nClone: W23166E\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Delta and Notch-like epidermal growth factor-related receptor (DNER), BET, UNQ26\/PRO299, HE60\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866439110825,"sku":"654652","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-654652","provider":"Iright","version":"1.0","type":"link"}