{"product_id":"biolegend-655802","title":"Biolegend, 655802, Purified anti-c-REL Antibody, 100μg","description":"\u003cp\u003ec-Rel is a member of the Rel\/NF-κB transcription factor family that forms homo or heterodimers with family members such as RelA\/p65, RelB, NF-κB1\/p105, and NF-κB2\/p100. The NF-κB complex is retained in cytoplasm by the inhibitor IκB protein in unstimulated cells. Upon activation, IκB is degraded via the ubiquitin-proteasome pathway, which results in nuclear translocation of the active NF-κB complex. While other NF-κB transcription factors are expressed in most cell types, relatively higher levels of c-REL expression are found in hematopoietic cells. c-REL is thought to play key roles in regulating proliferation, differentiation, and survival of B and T lymphocytes.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Partial c-REL recombinant protein (453-587 a.a.)\u003cbr\u003e\nFormulation: This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: Affinity purified\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: Upon receipt, store undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested ChIP - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. For ChIP applications, the suggested dilution is 1:50-1:100 by volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2562203 (BioLegend Cat. No. 655802)\u003cbr\u003e\nStructure: 619 amino acids, predicted molecular weight of 69 kD, contains a RHD (Rel-like) domain responsible for dimerization and DNA binding, contains two C-terminal transactivation domains\u003cbr\u003e\nDistribution: Cytoplasm, translocated to the nucleus upon activation\u003cbr\u003e\nFunction: Transcription factor belonging to the NF-κB family, regulates various biological processes including tumorgenesis, inflamation, immune response, cell proliferation, and differentiation\u003cbr\u003e\nInteraction: Forms homo or heterodimer with other NF-κB family members; interacts with NKIRAS1, NFKBIB, NFKBIE, IRF-8, and Foxp3\u003cbr\u003e\nCell Type: B cells, Tregs\u003cbr\u003e\nBiology Area: Apoptosis\/Tumor Suppressors\/Cell Death, Cell Biology, Cell Cycle\/DNA Replication, Immunology, Signal Transduction, Transcription Factors\u003cbr\u003e\nMolecular Family: Nuclear Markers, TCRs\u003cbr\u003e\nAntigen References: 1. Bash J, et al. 1997. Mol. Cell Biol. 17:6526. 2. Chen G, et al. 2010. J. Immunol. 185:2350. 3. Gilmore TD, et al. 2011. Genes Cancer 2:695. 4. Ferch U, et al. 2007. Nat. Immunol. 8:984. 5. Sanjabi S, et al. 2005. Genes Dev. 19:2138. 6. Yamazaki T, et al. 2003. Nat. Immunol. 4:780.\u003cbr\u003e\nGene ID: 5966\u003cbr\u003e\nUniProt: View information about c-REL on UniProt.org\u003cbr\u003e\nClone: 2F5A22\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: REL, V-Rel Avian Reticuloendotheliosis Viral Oncogene Homolog, Proto-Oncogene C-Rel\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864368271529,"sku":"655802","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-655802","provider":"Iright","version":"1.0","type":"link"}