{"product_id":"biolegend-660402","title":"Biolegend, 660402, Purified anti-CCL11 (Eotaxin) Antibody, 100μg","description":"\u003cp\u003eCCL11 selectively recruits eosinophils through binding to the chemokine receptor CCR3 during allergic response. CCL11 production is upregulated in response to several proimflammatory cytokines, such as IL-4, IL-13, TNF-α, and IFN-α, produced by mast cells and Th2 lymphocytes. CCL11 has been reported to stimulate eosinophil release from bone marrow, resulting in an elevated level of circulating eosinophils.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Human CCL11 recombinant protein (Gly24-Pro97) expressed in E. coli.\u003cbr\u003e\nFormulation: This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: Affinity purified.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: Upon receipt, store undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2563471 (BioLegend Cat. No. 660402)\u003cbr\u003e\nStructure: 74 amino acid, predicted molecular weight of approximately 12 kD.\u003cbr\u003e\nDistribution: Secreted. Epithelial cells, smooth muscle cells, dendritic cells, and fibroblasts.\u003cbr\u003e\nInteraction: Eosinophils\u003cbr\u003e\nLigand\/Receptor: CCR3\u003cbr\u003e\nCell Type: Dendritic cells, Eosinophils, Epithelial cells, Fibroblasts\u003cbr\u003e\nBiology Area: Angiogenesis, Cell Biology, Immunology, Neuroinflammation, Neuroscience\u003cbr\u003e\nMolecular Family: Cytokines\/Chemokines\u003cbr\u003e\nAntigen References: 1. Conroy DM, et al. 2001. Respir. Res. 2:150. 2. Levina V, et al. 2009. Clin. Cancer Res. 15:2647. 3. Salcedo R, et al. 2001. J. Immunol. 166:7571. 4. Kaehler J, et al. 2006. J. Investig. Med. 54:446. 5. Hadjicharalambous C, et al. 2004. J. Allergy Clin. Immunol. 113:657. 6. Crump MP, et al. 1998. J. Biol. Chem. 273:22471.\u003cbr\u003e\nGene ID: 6356\u003cbr\u003e\nUniProt: View information about CCL11 on UniProt.org\u003cbr\u003e\nClone: L402H11\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Chemokine (C-C Motif) ligand 11, Eotaxin-1, Eosinophil chemotactic protein, Small-inducible cytokine A11\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866123096233,"sku":"660402","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-660402","provider":"Iright","version":"1.0","type":"link"}