{"product_id":"biolegend-664304","title":"Biolegend, 664304, Purified anti-, 100μg","description":"\u003cp\u003eCRP (also known as cAMP receptor protein) is a regulatory protein in bacteria. CRP binding to cAMP leads to conformational changes in CRP resulting in a dramatic increase in its binding to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA and acts as a negative regulator of its own synthesis.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: E. coli\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Purified protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nStorage \u0026amp; Handling: This antibody should be handled aseptically as it is free of preservatives such as Sodium Azide. Store this antibody undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check the vial label or CoA to find the proper storage conditions.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.25 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nProduct Citations: Huang Y, et al. 2022. Gut Microbes. 14:2136460. PubMed Gibson JA, et al. 2022. Proc Natl Acad Sci U S A. 119:e2210115119. PubMed Lauritsen I, et al. 2021. Nat Commun. 12:5880. PubMed Ayhan D, et al. 2016. PLoS Biol. 14: 1002552. PubMed Seok JY, et al. 2021. Cell Reports. 36(8):109589. PubMed Pryor R et al. 2019. Cell. 178(6):1299-1312 . PubMed\u003cbr\u003e\nRRID: AB_2565553 (BioLegend Cat. No. 664304)\u003cbr\u003e\nStructure: 210 amino acids with a predicted molecular weight of approximately 23.5 kD.\u003cbr\u003e\nDistribution: Bacteria.\u003cbr\u003e\nFunction: Transcriptional regulator in bacteria.\u003cbr\u003e\nLigand\/Receptor: cAMP\u003cbr\u003e\nBiology Area: Cell Biology, Transcription Factors\u003cbr\u003e\nAntigen References: 1. Busby S, et al. 1999. J. Mol. Biol. 293:199. 2. Lawson CL, et al. 2004. Curr. Opin. Struct. Biol. 14:10. 3. Hudson BP, et al. 2009. Proc. Natl. Acad. Sci. USA 106:19830.\u003cbr\u003e\nGene ID: 1036667\u003cbr\u003e\nUniProt: View information about CRP on UniProt.org\u003cbr\u003e\nClone: 1D8D9\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: cAMP receptor protein, cAMP regulatory protein, Catabolite gene activator, cap, csm\u003cbr\u003e\nIsotype: Mouse IgG1\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860856688809,"sku":"664304","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-664304","provider":"Iright","version":"1.0","type":"link"}