{"product_id":"biolegend-666904","title":"Biolegend, 666904, Purified anti-CA125 Antibody, 100μg","description":"\u003cp\u003eCA125 is believed to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. It binds to MSLN, which mediates heterotypic cell adhesion. This may contribute to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium through its binding to MSLN.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Endogenous protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality testedIHC-P - VerifiedFC - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.5 µg per ml. For immunohistochemistry, a concentration range of 0.5 - 5 µg per ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: The observed molecular weight of this target is ~500 kD, which is considerably different than the predicted MW of 1519 kD. Similar observed molecular weights were confirmed using control antibodies from other vendors and have been reported by other vendors.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Goodell CA, et al. 2009. J. Ovarian Res. 2:8. (FC)\u003cbr\u003e\nRRID: AB_2629540 (BioLegend Cat. No. 666904)\u003cbr\u003e\nStructure: CA125 is a 250 kD+ protein.\u003cbr\u003e\nBiology Area: Cancer Biomarkers, Cell Biology\u003cbr\u003e\nAntigen References: 1. Yin BW, et al. 2001. J. Biol. Chem. 276:27371. 2. Duraisamy S, et al. 2006. Gene. 373:28. 3. Bast RC Jr, et al. 1998. Int. J. Biol. Markers 13:179.\u003cbr\u003e\nGene ID: 9402573732\u003cbr\u003e\nUniProt: View information about CA125 on UniProt.org\u003cbr\u003e\nClone: 618F\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Mucin-16, MUC-16, MUC16, Ovarian cancer-related tumor marker CA125, CA-125, Ovarian carcinoma antigen CA125, CA125\u003cbr\u003e\nIsotype: Mouse IgG1\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864375414953,"sku":"666904","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-666904","provider":"Iright","version":"1.0","type":"link"}