{"product_id":"biolegend-669802","title":"Biolegend, 669802, Purified anti-Skp1 Antibody, 100μg","description":"\u003cp\u003eS-phase kinase-associated protein 1 (Skp1) is one of the components of the SCF complex, which belongs to the E3 ubiquitin-protein ligase family. The SCF complex recruits substrates and promotes ubiquitin-mediated degradation of the substrates. Skp1 forms an invariable core component of the SCF complex with Cul1 and Rbx1 proteins. Skp1 binds to F-box proteins, which recruit the substrates for proteolysis.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Full length recombinant human Skp1 protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.1 - 1.0 µg\/mL. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: This clone recognizes human Skp1 and cross-reacts with mouse Skp1.When tested for WB, this clone detected a ~40 kDa protein of unknown origin; this band was not observed at lower antibody titrations.Because of the binding of this antibody to the unknown protein, this clone was not tested for ICC.This clone failed IP testing.\u003cbr\u003e\nRRID: AB_2820110 (BioLegend Cat. No. 669801) AB_2820111 (BioLegend Cat. No. 669802)\u003cbr\u003e\nStructure: Skp1 is a 163 amino acid protein with a predicted molecular weight of 19 kD.\u003cbr\u003e\nDistribution: Centrosome\/Cytosol\/Nucleus\/Ubiquitously expressed\u003cbr\u003e\nFunction: Adaptor protein\u003cbr\u003e\nBiology Area: Cell Biology, Ubiquitin\/Protein Degradation\u003cbr\u003e\nMolecular Family: Adaptor Proteins\u003cbr\u003e\nAntigen References: Bai C, et al. 1996. Cell. 86:263 Zheng N, et al. 2002. Nature. 416:703 Schulman B, et al. 2000. Nature. 408:381\u003cbr\u003e\nGene ID: 6500\u003cbr\u003e\nUniProt: View information about Skp1 on UniProt.org\u003cbr\u003e\nClone: W18108A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: S-Phase Kinase Associated Protein 1 , Transcription Elongation Factor B Polypeptide 1-Like, Cyclin-A\/CDK2-Associated Protein P19, Organ Of Corti Protein II, P19skp1, OCP-II, TCEB1L, SKP1A, EMC19, SIII,RNA Polymerase II Elongation Factor-Like Protein\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866333401257,"sku":"669802","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-669802","provider":"Iright","version":"1.0","type":"link"}