{"product_id":"biolegend-673252","title":"Biolegend, 673252, Purified anti-SNAIL Antibody, 100μg","description":"\u003cp\u003eSNAIL is a zinc finger transcriptional repressor that is involved in cell movement, adhesion, and survival. SNAIL plays a pivotal role in the epithelial to mesenchymal transition (EMT) during embryonic development. SNAIL represses the expression of E-cadherin in epithelial cells leading to the disassembly of cell-cell junctions, loss of cell polarity, and increased migration. In pathological contexts, SNAIL can promote tumor progression and metastasis by allowing cancer cells to invade surrounding tissues.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant fragment of human SNAIL protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested ICC, ICFC - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.25 - 1.0 µg\/mL. For immunocytochemistry, a concentration range of 1.0 - 10.0 μg\/mL is recommended. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: For use of this antibody in immunocytochemistry (ICC), we recommend fixation\/permeabilization with PFA 2% and Triton X-100 0.5%. We do not recommend PFA\/methanol or methanol alone.\u003cbr\u003e\nRRID: AB_3683495 (BioLegend Cat. No. 673251) AB_3683495 (BioLegend Cat. No. 673252)\u003cbr\u003e\nStructure: SNAIL is a 264 amino acid protein with a molecular weight of approximately 29 kDa.\u003cbr\u003e\nDistribution: SNAIL is primarily located in the nucleus of the cell but can be transported to the cytoplasm upon phosphorylation.\u003cbr\u003e\nFunction: EMT, embryonic development, cell migration\u003cbr\u003e\nInteraction: FBXL14, GSK3B, BTRC, WTIP, LIMD1 LOXL2 and LOXL3, CSNK2A1, EGR1, LATS2, KPNB1, TNPO1, KPNA1, KPNA4, IPO7, PARP1, KDM1A, p53, NOTCH1, MDM2, CSNK1E, and PAK1\u003cbr\u003e\nAntigen References: Dong B, et al. 2021. Int J Mol Sci. 22:11062. Olmeda D, et al. 2007. Cancer Res. 67:11721. Baulida J, et al. 2019. J Clin Med. 8: 757. Suzuki T, et al. 2023. J Cancer Metastasis Treat. 9:25. Sun JX, et al. 2018. Angiogenesis. 21:635.\u003cbr\u003e\nGene ID: 6615\u003cbr\u003e\nUniProt: View information about SNAIL on UniProt.org\u003cbr\u003e\nClone: W22252A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: SNAI1, Snail Family Transcriptional Repressor, SNAH, SLUGH2, SNAIL, SNA, Snail Family Zinc Finger 1, Zinc Finger Protein SNAI1\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866435735721,"sku":"673252","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-673252","provider":"Iright","version":"1.0","type":"link"}