{"product_id":"biolegend-682102","title":"Biolegend, 682102, Purified anti-HSC70 (HSPA8) Antibody, 100μg","description":"\u003cp\u003eHeat shock cognate 71 kD protein or HSC70 (HSPA8) is one of the major constitutively expressed, cognate protein chaperones to supply a multitude of the housekeeping chaperoning functions. As a chaperone, HSC70 binds to nascent polypeptides to facilitate correct folding. Besides the chaperone functions, secreted HSC70 is involved in inflammatory signal pathways via extracellular interaction with TLR2\/TLR4. It also plays a central role in modulating antigen transport within cells to control MHC class II presentation during nutrient stress. Furthermore, HSC70 may serve as a molecular switch to modulate endocytic and autophagy pathways.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Purified recombinant human HSC70 fragment (1-1755bp of Acc. Y00371)\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested KO\/KD-WB - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2566574 (BioLegend Cat. No. 682102)\u003cbr\u003e\nStructure: 646 amino acids with a predicted molecular weight of approximately 71 kD.\u003cbr\u003e\nDistribution: Cytoplasm, nucleus, and cell membrane.\u003cbr\u003e\nFunction: Chaperone and antigen transport.\u003cbr\u003e\nInteraction: PACRG, HSPH1\/HSP105, IRAK1BP1, BAG1, DNAJC7, DNAJB14, E3 ligase CHIP, CITED1 , CDC5L, PLRG1 and BCAS2, SV40 VP1, TRIM5, METTL21A, PARK2, and FOXP3.\u003cbr\u003e\nBiology Area: Cell Biology, Cell Cycle\/DNA Replication, Chromatin Remodeling\/Epigenetics, Immunology, Innate Immunity, Neurodegeneration, Neuroinflammation, Neuroscience, Protein Trafficking and Clearance, Signal Transduction, Transcription Factors\u003cbr\u003e\nMolecular Family: Heat Shock Proteins, Protein Kinases\/Phosphatase\u003cbr\u003e\nAntigen References: 1. Deffit SN, Blum JS. 2015. Mol. Immunol. 68:85-8. 2. Pratt WB, et al. 2015. Annu. Rev. Pharmacol. Toxicol. 55:353. 3. Stricher F, et al. 2013. Autophagy 9:1937. 4. Liao Y, et al. 2014. Curr. Pharm. Des. 20:101. 5. Höhfeld J. 1998. Biol. Chem. 379:269.\u003cbr\u003e\nGene ID: 3312\u003cbr\u003e\nUniProt: View information about HSC70 on UniProt.org\u003cbr\u003e\nClone: 9\/2\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Heat Shock 70 kD Protein 8, HSP70, HSP73, HSPA10, Heat Shock Cognate Protein 54, HSC54, heat stress cognate 70\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862497644713,"sku":"682102","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/biolegend-682102","provider":"Iright","version":"1.0","type":"link"}